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| http://dx.doi.org/10.11604/pamj.2014.19.84.5165 | DOI Listing |
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Treating adult patients of severe psoriasis with methotrexate leads to reduction in biomarkers of atherosclerosis: A prospective study.
Med J Armed Forces India
December 2024
Commanding Officer, 2118 Field Hospital, C/o 56 APO, India.
Background: Psoriasis is a common skin disorder; affecting 0.4-2% of general population and is associated with increased risk of cardiovascular diseases. We conducted this prospective study to determine change in biomarkers of atherosclerosis in plaque psoriasis in patients treated with methotrexate.
View Article and Find Full Text PDFSystemic treatment type is not associated with abnormal post-treatment noninvasive liver stiffness measurement in psoriasis.
Front Immunol
December 2024
Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.
Background: Psoriasis is commonly associated with metabolic dysfunction-associated steatotic liver disease, raising concerns about the hepatic effects of systemic treatments on psoriasis and its comorbid conditions. This study evaluates liver stiffness measurement (LSM) alterations and identifies predictors of abnormal LSM in psoriatic patients following systemic treatments, including biologics and methotrexate.
Methods: This prospective cohort study is based on the PSOWCH database (Psoriasis Cohort of West China Hospital).
Early Methotrexate Treatment For Psoriatic Arthritis Prevention in Psoriasis Patients - a retrospective cohort study.
Joint Bone Spine
December 2024
Faculty of Medical and Health Sciences, Tel-Aviv University, P.O.B 39040, Ramat Aviv, Tel Aviv, 69978, Israel; Rheumatology Unit, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel. Electronic address:
Objectives: Early initiation of biologic therapies for psoriasis has been explored to prevent or delay the onset of psoriatic arthritis (PsA). This has renewed interest in the potential role of methotrexate (MTX) in mitigating PsA risk in newly diagnosed psoriasis patients. The aim of this study was to evaluate the impact of early MTX initiation on PsA incidence in individuals with psoriasis.
View Article and Find Full Text PDFPsoriasis: Perspectives from Irwin M. Braverman, MD.
Clin Dermatol
December 2024
Department of Dermatology, Yale School of Medicine, New Haven, CT; Program in Translational Biomedicine, Yale University, New Haven, CT.
Dr. Irwin M. Braverman is recognized as an expert on many skin diseases including psoriasis, an immune-mediated disorder that presents with scaly erythematous plaques.
View Article and Find Full Text PDFCombined fractional CO2 laser 10,600 nm with methotrexate 1% gel versus methotrexate 1% gel alone in the treatment of nail psoriasis: a randomized comparative study.
Arch Dermatol Res
December 2024
Department of Dermatology and Venereology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Methotrexate injections intralesionally as a treatment for psoriatic nails proved to be effective in large-scale studies as well as individual case reports, but the process is painful and time-consuming. The objective of this study was to compare the efficacy and safety of combined fractional CO2 laser (Fr. CO2) 10,600 nm and methotrexate gel versus methotrexate 1% gel alone in treatment of nail psoriasis.
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