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The efficacy of methylene blue encapsulated in silica nanoparticles compared to naked methylene blue for photodynamic applications. | LitMetric
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The efficacy of methylene blue encapsulated in silica nanoparticles compared to naked methylene blue for photodynamic applications.

Ghaseb Naser Makhadmeh Azlan Abdul Aziz Khairunisak Abdul Razak

Artif Cells Nanomed Biotechnol

b Engineering Department, School of Materials and Mineral Resources Engineering , Universiti Sains Malaysia, Penang , Malaysia.

Published: May 2016

Background/aims: This study analyzed the physical effects of methylene blue (MB) encapsulated within silica nanoparticles (SiNPs) in photodynamic therapy.

Materials And Methods: The optimum concentration of MB needed to destroy red blood cells (RBCs) was determined, and the efficacy of encapsulated MB-SiNPs compared to that of naked MB was verified.

Results: The results confirmed the applicability of MB encapsulated in SiNPs on RBCs, and established a relationship between the concentration of the SiNP-encapsulated MB and the time required to rupture 50% of the RBCs (t50).

Conclusion: The MB encapsulated in SiNPs exhibited higher efficacy compared to that of naked MB.

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 Source
http://dx.doi.org/10.3109/21691401.2015.1008511DOI Listing

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