Objective: To compare reproductive outcomes of patients with very low, low, normal, and high antral follicle counts undergoing unstimulated therapeutic donor insemination (TDI) cycles.
Design: Retrospective cohort study.
Setting: University-affiliated regional fertility clinic.
Patient(s): Four hundred fifty-nine patients who had 1,107 TDI treatment cycles from January 2006 to December 2013.
Intervention(s): Unstimulated therapeutic donor insemination.
Main Outcome Measure(s): Clinical pregnancy rates and miscarriage rates as surrogate markers for oocyte quality.
Result(s): The overall pregnancy rate per cycle start was 12.46% in the study population. There was no difference in per-cycle or cumulative pregnancy rates among patients with very low, low, average, or high antral follicle counts within each patient age group of ≤35, 36-39, and ≥40 years. The overall miscarriage rate per pregnancy was 13.61%. When stratified by patient age, there was no correlation between miscarriage rate and antral follicle count.
Conclusion(s): AFC is not a predictor of pregnancy or miscarriage rates in patients undergoing unstimulated TDI.
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