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Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. | LitMetric

AI Article Synopsis

  • Epithelial organ development involves precise coordination of cell growth and differentiation, with endocytosis playing a crucial role, but its specific regulatory functions remain unclear.
  • The study explains how plasmolipin (PLLP) in zebrafish enhances the availability of endosomal SNARE receptors, aiding in the morphogenesis of epithelial tissues by influencing polarized endocytosis.
  • PLLP not only helps sort the SNARE proteins but also promotes the internalization of Crumbs and activates the Notch signaling pathway, both essential for establishing cell polarity and differentiation in epithelial cells.

Article Abstract

Epithelial organs develop through tightly coordinated events of cell proliferation and differentiation in which endocytosis plays a major role. Despite recent advances, how endocytosis regulates the development of vertebrate organs is still unknown. Here we describe a mechanism that facilitates the apical availability of endosomal SNARE receptors for epithelial morphogenesis through the developmental upregulation of plasmolipin (pllp) in a highly endocytic segment of the zebrafish posterior midgut. The protein PLLP (Pllp in fish) recruits the clathrin adaptor EpsinR to sort the SNARE machinery of the endolysosomal pathway into the subapical compartment, which is a switch for polarized endocytosis. Furthermore, PLLP expression induces apical Crumbs internalization and the activation of the Notch signalling pathway, both crucial steps in the acquisition of cell polarity and differentiation of epithelial cells. We thus postulate that differential apical endosomal SNARE sorting is a mechanism that regulates epithelial patterning.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126975PMC
http://dx.doi.org/10.1038/ncb3106DOI Listing

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