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Artificial neural network-driven modeling of Ebola transmission dynamics with delays and disability outcomes.
Comput Biol Chem
January 2025
Department of Mathematics, College of Science, Qassim University, Buraydah 51452, Saudi Arabia.
This study develops an Artificial Neural Network (ANN)-based framework to model the transmission dynamics and long-term disability outcomes of Ebola Virus Disease (EVD). Building on existing deterministic SEIR models, we extend the framework by introducing a disability compartment, capturing the progression of Ebola survivors to chronic health complications, such as post-Ebola syndrome. The proposed model stratifies the population into various epidemiological states, incorporating delays to better reflect the natural progression and intervention strategies associated with EVD.
View Article and Find Full Text PDFExploring perceptions and attitudes towards vaccines in a remote western DRC health zone.
Vaccine X
January 2025
Global Health Institute, Department of Family Medicine and Population Health, University of Antwerp, Antwerp, Belgium.
The Democratic Republic of the Congo (DRC) struggles with low full childhood vaccination coverage (around 50 %) and a high children-under-five mortality rate (79 deaths per 1000 live births). This situation is potentially exacerbated by vaccine hesitancy, which was identified by the World Health Organization (WHO) as one of the top 10 global health threats in 2019. To gain deeper insights into levels of vaccine confidence possibly influencing vaccination coverage, we explored perceptions and attitudes towards childhood and adult vaccines in Boende (Tshuapa province, western DRC), which experienced an Ebola outbreak in 2014 and hosted the EBL2007 Ebola vaccine trial (2019-2022).
View Article and Find Full Text PDFNew reverse sum Revan indices for physicochemical and pharmacokinetic properties of anti-filovirus drugs.
Front Chem
December 2024
Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Chennai, Tamil Nadu, India.
Ebola and Marburg viruses, biosafety level 4 pathogens, cause severe hemorrhaging and organ failure with high mortality. Although some FDA-approved vaccines or therapeutics like Ervebo for Zaire Ebola virus exist, still there is a lack of effective therapeutics that cover all filoviruses, including both Ebola and Marburg viruses. Therefore, some anti-filovirus drugs such as Pinocembrin, Favipiravir, Remdesivir and others are used to manage infections.
View Article and Find Full Text PDFCorneal and conjunctival abnormalities in a cohort of survivors from the Western African Ebola virus disease outbreak.
AJO Int
December 2024
Truhlsen Eye Institute, Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Purpose: To characterize corneal and conjunctival abnormalities (CCAs) and their impact on visual acuity in a cohort of survivors from the Western African Ebola virus disease (EVD) outbreak.
Design: A post hoc analysis of 121 patients, who had previously undergone screening for the Ebola Virus Persistence in Ocular Tissues and Fluids study, was performed.
Methods: Patients underwent a comprehensive ophthalmic exam at the Lowell and Ruth Gess Eye Hospital in Freetown, Sierra Leone.
Unraveling the effects of the Ebola experience on behavior choices during COVID-19 in Liberia: a mixed-methods study across successive outbreaks.
BMC Glob Public Health
April 2024
College of Health Sciences, University of Liberia, Monrovia, Liberia.
Background: The burden of the COVID-19 pandemic in terms of morbidity and mortality differentially affected populations. Between and within populations, behavior change was likewise heterogeneous. Factors influencing precautionary behavior adoption during COVID-19 have been associated with multidimensional aspects of risk perception; however, the influence of lived experiences during other recent outbreaks on behavior change during COVID-19 has been less studied.
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