An enantioselective Pd-catalyzed 6--trig reaction for the synthesis of 2-aryl-chromenes has been developed. A systematic optimization of a TADDOL-derived ligand set resulted in the identification of a novel monodentate phosphoramidite-palladium catalyst that accesses 2-aryl--chromenes with high yield and enantioselectivity under mild conditions. The products obtained from this method can be transformed into biologically active compounds through functionalization of the chromene alkene.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334165 | PMC |
| http://dx.doi.org/10.1039/C4SC00423J | DOI Listing |
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