AI Article Synopsis
- A study analyzed liver enzyme levels in 112 patients with serious infections, excluding cases influenced by other causes.
- About 70% of patients showed altered liver enzyme values, with GGT having the highest prevalence at 39.1%.
- The findings indicated that these enzyme changes are nonspecific to the type of infection and bilirubin levels were notably higher in patients who did not survive, suggesting a possible common mechanism behind the changes.
Article Abstract
To establish the prevalence of liver enzyme alterations in the course of serious infections of diverse origin, 112 patients were studied retrospectively for the levels of GOT, GPT, LDH, GGT, alkaline phosphatase (FA) and bilirubin (BIL). Cases in which the values might be altered due to causes other than the infectious process were previously excluded. The prevalence of affectation of each of the parameters was the following: GGT, 39.1%; LDH, 33.3%; FAL, 30.1%; GOT, 29.5%; GPT, 24.8%; BIL, 18.3%. Seventy percent had at least one of these values changed. No significant differences were found in the incidence or intensity of the analytic alterations in function of the origin of the of infection, which suggests that these modification are nonspecific. Bilirubin levels were found to be significantly higher in the patients who died. On realizing the linear correlation analysis between the diverse parameters studied, a good correlation was found between them, suggesting a common pathogenetic mechanism.
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