Little attention is paid in prevention research to the ability of measures to accurately assess change, termed "responsiveness" or "sensitivity to change." This paper reviews definitions and measures of responsiveness, and suggests five strategies for increasing sensitivity to change, with central focus on prevention research with small samples: (a) improving understandability and cultural validity, (b) assuring that the measure covers the full range of the latent construct being measured, (c) eliminating redundant items, (d) maximizing sensitivity of the device used to collect responses; and (e) asking directly about change. Examples of the application of each strategy are provided. The discussion focuses on using the issues as a checklist for improving measures and the implications of sensitivity to change for prevention research with small samples.
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http://dx.doi.org/10.1007/s11121-015-0545-z | DOI Listing |
Mol Clin Oncol
February 2025
Department of Urology Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Disulfidptosis, which was recently identified, has shown promise as a potential cancer treatment. Nonetheless, the precise role of long non-coding RNAs (lncRNAs) in this phenomenon is currently unclear. To elucidate their significance in bladder cancer (BLCA), a signature of disulfidptosis-related lncRNAs (DRlncRNAs) was developed and their potential prognostic significance was explored.
View Article and Find Full Text PDFEur Heart J Imaging Methods Pract
October 2024
Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Lund 221 00, Sweden.
Aims: 4D blood flow measurements by cardiac magnetic resonance imaging (CMR) can be used to simplify blood flow assessment. Compressed sensing (CS) can provide better flow measurements than conventional parallel imaging (PI), but clinical validation is needed. This study aimed to validate stroke volume (SV) measurements by 4D-CS in healthy volunteers and patients while also investigating the influence of the CS image reconstruction parameter on haemodynamic parameters.
View Article and Find Full Text PDFFront Allergy
December 2024
Department of Dermatology, Eberhard Karls University, Tuebingen, Germany.
Background: Allergy to beta-lactam antibiotics (BLA), especially to penicillin, is the most commonly reported drug allergy by patients. Alternative antibiotics can yield negative consequences, such as extended hospitalization days due to less efficacy and overall higher costs. The basophil activation test (BAT) is an assay, in which activation of an individual's own basophils is quantified by flow cytometry.
View Article and Find Full Text PDFJ Med Imaging (Bellingham)
January 2025
The University of Tokyo Hospital, Department of Radiology, Tokyo, Japan.
Purpose: The prevalence of type 2 diabetes mellitus (T2DM) has been steadily increasing over the years. We aim to predict the occurrence of T2DM using mammography images within 5 years using two different methods and compare their performance.
Approach: We examined 312 samples, including 110 positive cases (developed T2DM after 5 years) and 202 negative cases (did not develop T2DM) using two different methods.
Ther Adv Med Oncol
January 2025
Department of Oncology, Zhuzhou Second Hospital, Zhuzhou, Hunan 412000, China.
Background: Both the antibody-drug conjugate (ADC) enfortumab vedotin (EV) and programmed death-1 inhibitor pembrolizumab have been shown to provide survival benefits in patients previously treated with locally advanced or metastatic urothelial carcinoma (la/mUC). Cost-effectiveness is necessary to consider whether the increased efficacy of the two therapies will lead to higher prices for first-line treatment of previously untreated la/mUC.
Objectives: To guide the choice of EV plus pembrolizumab or chemotherapy for patients with previously untreated la/mUC.
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