AI Article Synopsis
- Non-small cell lung cancer (NSCLC) is a major cause of cancer deaths, with microRNAs (miRNAs) playing a crucial role in regulating gene expression related to cancer.
- Researchers analyzed miRNA expression in NSCLC tissues and identified 17 differentially expressed miRNAs compared to normal tissues, focusing on their potential roles in cancer regulation.
- Key findings included the identification of miR-34b, miR-520h, miR-22 as potential novel biomarkers, as well as miR-448 promoting and miR-654-3p preventing NSCLC progression, laying the groundwork for future clinical therapies.
Article Abstract
Background: Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer mortality. MicroRNAs (miRNAs), small noncoding RNAs, regulate the expression of genes that play roles in human cancer via posttranscriptional inhibition.
Methods: To identify the potential miRNA biomarkers in NSCLC, we downloaded the miRNA expression profile (ID: GSE29248) of NSCLC from the Gene Expression Omnibus (GEO) database and analyzed the differentially expressed miRNAs in NSCLC tissue compared with normal control tissue. Then the targets of these differentially expressed miRNAs were screened and used in network construction and functional enrichment analysis.
Results: We identified a total of 17 miRNAs that showed a significantly differential expression in NSCLC tissue. We found that miR-34b and miR-520h might play important roles in the regulation of NSCLC, miR-22 might be a novel biomarker as an oncogene, and miR-448 might promote, while miR-654-3p prevents, NSCLC progression.
Conclusions: Our study may provide the groundwork for further clinical molecular target therapy experiments in NSCLC.BAC
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| http://dx.doi.org/10.5301/tj.5000224 | DOI Listing |
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