In this review the current conceptions concerning zinc biology, its metabolism and transport into the cells, its homeostasis, a role in the functioning of the human immune and endocrine systems, participation in cell signaling and its cytotoxicity, as well as the biophysical mechanisms of action of zinc ions action at the elevated concentrations on human blood cells were analyzed.
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Gene deletion of Pregnancy-associated Plasma Protein-A (PAPP-A) improves pathology and cognition in an Alzheimer's disease mouse model.
Exp Neurol
December 2024
Department of Endocrinology, Mayo Clinic, Rochester, MN 55905, United States of America. Electronic address:
Article Synopsis
- Alzheimer's disease (AD) is a worsening brain condition without effective treatments, linked to the buildup of toxic β-amyloid peptides and amyloid plaques.
- Previous studies have connected the insulin-like growth factor (IGF) system to AD, and reduced IGF-I receptor (IGFIR) signaling can alleviate plaque formation and neurodegeneration in mice.
- Research highlighted that deleting PAPP-A, a protein involved in regulating IGF-I, in a mouse model of AD resulted in less plaque, improved brain function, and suggests that targeting PAPP-A could be a new treatment option for AD.
Exploring serum trace element shifts: Implications for cervical intraepithelial neoplasia.
J Trace Elem Med Biol
December 2024
Innovative Centre of the Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia. Electronic address:
Background: Cervical intraepithelial neoplasia (CIN) represents a premalignant state presumably related to perturbations in circulating levels of trace elements.
Materials And Methods: Employing inductively coupled plasma mass spectrometry (ICP-MS), we quantified essential and toxic trace elements in the sera of 60 women diagnosed with CIN and 60 age-matched healthy counterparts.
Results: Our investigation revealed a noteworthy higher levels in serum of Mn, Zn, and Pb, as well as lower levels in Ni, Se, Rb, and Mo levels within the CIN cohort.
Deep mutational scanning of EccD reveals the molecular basis of its essentiality in the mycobacterium ESX secretion system.
bioRxiv
August 2024
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Tuberculosis remains the deadliest infectious disease in the world and requires novel therapeutic targets. The ESX-3 secretion system, which is essential for iron and zinc homeostasis and thus survival, is a promising target. In this study, we perform a deep mutational scan on the ESX-3 core protein EccD in the model organism .
View Article and Find Full Text PDFGenetic Biofortification of Winter Wheat with Selenium (Se).
Plants (Basel)
July 2024
Department for Cereal Breeding and Genetics, Agricultural Institute Osijek, Južno Predgrađe 17, 31000 Osijek, Croatia.
Wheat is one of the three most important cereals in the world, along with rice and maize. It serves as the primary food and source of energy for about 30-40% of the world's population. However, the low levels of micronutrients in wheat grains can lead to deficiencies of those micronutrients in people whose dietary habits are mostly based on cereals such as wheat.
View Article and Find Full Text PDFElucidating the role of primary and secondary sphere Zn ligands in the cyanobacterial CO uptake complex NDH-1: The essentiality of arginine in zinc coordination and catalysis.
Biochim Biophys Acta Bioenerg
November 2024
Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078, USA. Electronic address:
Inorganic carbon uptake in cyanobacteria is facilitated by an energetically intensive CO-concentrating mechanism (CCM). Specialized Type-1 NDH complexes function as a part of this mechanism to couple photosynthetic energy generated by redox reactions of the electron transport chain (ETC) to CO hydration. This active site of CO hydration incorporates an arginine side chain as a Zn ligand, diverging from the typical histidine and/or cysteine residues found in standard CAs.
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