Antiinflammatory effects of L-carnitine supplementation (1000 mg/d) in coronary artery disease patients.

Nutrition

School of Nutrition, Chung Shan Medical University, Taichung, Taiwan; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:

Published: March 2015

Objective: Inflammation mediators have been recognized as risk factors for the pathogenesis of coronary artery disease (CAD). The purpose of this study was to investigate the effect of L-carnitine supplementation (LC, 1000 mg/d) on inflammation markers in patients with CAD.

Methods: We enrolled 47 patients with CAD in the study. The patients with CAD were identified by cardiac catheterization as having <50% stenosis of one major coronary artery. The patients were randomly assigned to the placebo (n = 24) and LC (n = 23) groups and the intervention was administered for 12 wk. The levels of LC, antioxidant status (malondialdehyde and antioxidant enzymes activities), and inflammation markers (C-reactive protein [CRP], interleukin [IL]-6, and tumor necrosis factor [TNF]-α) were measured.

Results: Thirty-nine participants completed the study (19 placebo; 20 LC). After LC supplementation, the levels of inflammation markers were significantly reduced compared with the baseline (CRP, P < 0.01; IL-6, P = 0.03; TNF-α, P = 0.07) and those in the placebo group (CRP, P < 0.05; IL-6, P = 0.04; TNF-α, P = 0.03). The levels of inflammation markers were significantly negatively correlated with the levels of LC and antioxidant enzymes activities (P < 0.05).

Conclusions: We suggest that LC supplementation, due to its antioxidant effects, may have potential utility to reduce inflammation in CAD.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nut.2014.10.001DOI Listing

Publication Analysis

Top Keywords

l-carnitine supplementation
8
supplementation 1000
8
1000 mg/d
8
coronary artery
8
artery disease
8
patients cad
8
antiinflammatory effects
4
effects l-carnitine
4
mg/d coronary
4
patients
4

Similar Publications

Background: Chronic kidney disease (CKD) affects 10% of the global population and leads to end-stage renal disease (ESRD). Hemodialysis is a common treatment for ESRD, but patients often have low carnitine levels, leading to dyslipidemia, a risk factor for cardiovascular disease and the leading cause of mortality. This study aimed to assess the effects of L-carnitine on lipid profiles in adult hemodialysis patients.

View Article and Find Full Text PDF

Lipids in cumulus-oocyte complexes are important actors in molecular signalling pathways and are influenced by maturation conditions. Acetyl-L-carnitine (ALC) is a carrier involved in fatty acid transport and is a promoter of β-oxidation. Although the embryonic development potential of oocytes can be improved when ALC is added to the maturation medium, the effects of ALC on the lipid content and composition of oocytes and cumulus cells remain unknown.

View Article and Find Full Text PDF

Mitochondrial dysfunction has been implicated in the pathogenesis of several neurodegenerative disorders, including progressive supranuclear palsy (PSP). PSP is a Parkinsonian syndrome characterized by a rapidly progressive state that manifests itself as tremors, bradykinesia, and supranuclear gaze palsy. Carnitine plays an essential role in mitochondrial function by transporting fatty acids across the mitochondrial membrane to be used in energy production.

View Article and Find Full Text PDF
Article Synopsis
  • Exertional heatstroke (EHS) can cause serious harm to the heart and other organs, highlighting the need for effective treatment strategies.
  • This study focused on the impact of L-carnitine (LC) in protecting against cardiac damage and dysfunction caused by EHS in rats, revealing that LC significantly improves heart health by reducing cell death and harmful changes in heart tissue.
  • The protective effects of LC are linked to its ability to inhibit the PERK pathway, which is involved in stress responses in cells, suggesting that LC supplementation may be a promising approach to mitigate heart injury in EHS cases.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!