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Dexamethasone Delivery via Amphiphilic, Low-swelling Hydrogels Treats Postoperative Inflammation in Cervical Spine Applications.
Adv Healthc Mater
January 2025
Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332-0363, USA.
Anterior cervical spine surgeries are often complicated by difficulty swallowing due to local postoperative swelling, pain, scarring, and tissue dysfunction. These postoperative events lead to systemic steroid and narcotic use. Local, sustained drug delivery may address these problems, but current materials are unsafe for tight surgical spaces due to high biomaterial swelling, especially upon degradation.
View Article and Find Full Text PDFSpatial joint hazard assessment of landslide susceptibility and intensity within a single framework: Environmental insights from the Wenchuan earthquake.
Sci Total Environ
January 2025
HEOA - West China Health & Medical Geography Group, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610044, China; Institute for Healthy Cities and West China Research Centre for Rural Health Development, West China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan 610044, China. Electronic address:
To comprehensively assess regional landslide hazards, we propose a geospatial approach that jointly evaluates both the probability of occurrence (susceptibility) and potential destructive power (intensity) within a single framework, overcoming the limitations of previous studies that treated these two disaster scenarios independently. Focusing on the largest landslide event triggered by the Wenchuan earthquake in China, we collected landslide occurrence and count data at the slope unit level, alongside 18 environmental factors, including seismic data. To enable this multi-hazard single-framework evaluation, we employed two Bayesian spatial joint regressions: the spatial shared component model (SSCM) and the spatial shared hyperparameter model (SSHM).
View Article and Find Full Text PDFNeutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost.
Nat Commun
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Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Neutralizing antibody titer has been a surrogate endpoint for guiding COVID-19 vaccine approval and use, although the pandemic's evolution and the introduction of variant-adapted vaccine boosters raise questions as to this surrogate's contemporary performance. For 985 recipients of an mRNA second bivalent or monovalent booster containing various Spike inserts [Prototype (Ancestral), Beta, Delta, and/or Omicron BA.1 or BA.
View Article and Find Full Text PDFAssociation of Step Count with Cardiorespiratory Fitness: Results from the Virtual 2-Minute Step Test.
Arch Rehabil Res Clin Transl
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Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
Objective: To test the hypothesis that step count based on a virtual 2-minute step test (2MST) predicts cardiorespiratory fitness (CRF).
Design: Cross-sectional study.
Setting: Veteran Affairs Medical Centers participating in a randomized trial of functional exercise training delivered by videoconferencing.
Navigating "regulatory fog": Challenges to rigorous abortion research after the Dobbs v. Jackson decision.
Contraception
January 2025
Collaborative for Reproductive Equity, Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 1300 University Avenue, Medical Sciences Center 4245 Madison, WI 53706 USA. Electronic address:
In 2022, the United States' Supreme Court ruling in Dobbs v. Jackson Women's Health Organization overturned Roe v. Wade and federal protections for abortion.
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