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| http://dx.doi.org/10.3747/pdi.2014.00110 | DOI Listing |
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De novo gene synthesis by an antiviral reverse transcriptase.
bioRxiv
May 2024
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Bacteria defend themselves from viral infection using diverse immune systems, many of which sense and target foreign nucleic acids. Defense-associated reverse transcriptase (DRT) systems provide an intriguing counterpoint to this immune strategy by instead leveraging DNA synthesis, but the identities and functions of their DNA products remain largely unknown. Here we show that DRT2 systems execute an unprecedented immunity mechanism that involves de novo gene synthesis via rolling-circle reverse transcription of a non-coding RNA (ncRNA).
View Article and Find Full Text PDFCounterpoint: Defending pore theory.
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Department of Nephrology, Lund University, Lund, Sweden.
Insulin analogs--is there a compelling case to use them? No!
Diabetes Care
June 2014
Department of Internal Medicine, Charles R. Drew University, Los Angeles, CA
The availability of insulin analogs has offered insulin replacement strategies that are proposed to more closely mimic normal human physiology. Specifically, there are a considerable number of reports demonstrating that prandial insulin analogs (lispro, aspart, glulisine) have pharmacokinetic and pharmacodynamic profiles closer to normal, with resulting faster onset and offset of insulin effect when compared with regular human insulin. In addition, basal insulin analogs (glargine, detemir) have been reported to offer longer duration of action, less variability, more predictability, less hypoglycemia (especially nocturnal), and a favorable effect on weight.
View Article and Find Full Text PDFInsulin analogs-are they worth it? Yes!
Diabetes Care
June 2014
Grunberger Diabetes Institute, Bloomfield Hills, MI; Internal Medicine and Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI; and Oakland University William Beaumont School of Medicine, Rochester, MI
The availability of insulin analogs has offered insulin replacement strategies that are proposed to more closely mimic normal human physiology. Specifically, there are a considerable number of reports demonstrating that prandial insulin analogs (lispro, aspart, glulisine) have pharmacokinetic and pharmacodynamic profiles closer to normal, with resulting faster onset and offset of insulin effect when compared with regular human insulin. In addition, basal insulin analogs (glargine, detemir) have been reported to offer longer duration of action, less variability, more predictability, less hypoglycemia (especially nocturnal), and a favorable effect on weight.
View Article and Find Full Text PDFIn the following point-counterpoint article, internationally-acclaimed myopia researchers were challenged to defend the two opposing sides of the topic defined by the title; their contributions, which appear in the order Point followed by Counterpoint, were peer-reviewed by both the editorial team and an external reviewer. Independently of the invited authors, the named member of the editorial team provided an Introduction and Summary, both of which were reviewed by the other members of the editorial team. By their nature, views expressed in each section of the Point-Counterpoint article are those of the author concerned and may not reflect the views of all of the authors.
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