[Serum markers of inflammation and lipid-releasing ability of leukocytes in patients with arterial hypertension and angina of effort].

Detection of cardiovascular risk factors remains a challenging problem. The inflammatory mechanisms behind atherosclerosis imply active involvement of neutrophils and realization of lipid-releasing ability of leukocytes (LRAL) mediated through the synthesis of proatherogenic proteins with the formation of protein-lipid complexes accumulated around atherosclerotic lesions. Studies of compromised protein-synthesizing function and mechanisms regulating LRAL are currently underway. The aim of the present work was to investigate serum markers of inflammation and LRAL in arterial hypertension (AH) without coronary heart disease (CHD) or AH + angina of effort. One group comprised 20 patients with AH without CHD the other included 20 patients with AH and CHD. Control group consisted of 18 healthy subjects. LRAL was measured in vitro in addition to serum IL-6, IL-8, CRP, and TNF-α. Effect of TNF-α on LRAL was evaluated in vitro in CHD patients. It was shown that mean LRAL in healthy subjects and patients with AH without CHD were not significantly different whereas IL-8 and CRP levels were markedly elevated in AH patients. Patients with AH and CHD had maximum LRAL and IL-6, IL-8, CRP, TNF-α levels. The study showed the possibility of increase in LRAL under effect of proinflammatory cytokines. LRFAL and inflammatory mechanisms contribute to the development of CHD and can be used for diagnostics of CHD in AH patients.