The aim of the work was to study hemodynamics and clinical symptoms before and after treatment of arterial hypertension (AH) and coronary heart disease (CHD) using angiotensin II receptor blockers and angiotensin converting enzyme inhibitors depending on the patients' sex. A total of 150 patients with AH and CHD were examined (80 women and 70 men, mean age 70 a 66 yr respectively). Eighty two of them (group 1) were given receptor blockers (losap, losartan, lorista, bloctran) and 63 (group 2) inhibitors (prestarium, noliprel). Effectiveness of treatment was evaluated from the results of 24-hr AP monitoring, daily self-control of AP (as described by Korotkov) and responds to questionnaires. The effectiveness of receptor blockers showed marked gender-specific differences. Specifically, they reduced systolic and diastolic pressure and improved well-being in women. In men, this treatment decreased the frequency of angina attacks, headache, and heart throbs. Enzyme inhibitors caused a greater reduction of diastolic AP in women but less pronounced gender-related changes in dynamics of main AP and ECG parameters than receptor blockers.
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