We looked for mutations in the Plasmodium falciparum K13 propeller gene of an artemisinin-resistant parasite on islands in Lake Victoria, Kenya, where transmission in 2012-2013 was high. The 4 new types of nonsynonymous, and 5 of synonymous, mutations we detected among 539 samples analyzed provide clues to understanding artemisinin-resistant parasites.
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Temporal genomics in Southern Zambia shows rising prevalence of Plasmodium falciparum mutations linked to delayed clearance after artemisinin-lumefantrine treatment.
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- * In a study in southern Zambia from 2013 to 2018, researchers genotyped 85.5% of Plasmodium falciparum samples, finding only one sample with a known resistance mutation and identifying five new mutations with low prevalence.
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