Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1057/jphp.2015.4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Autophagy machinery plays an essential role in traumatic brain injury-induced apoptosis and its related behavioral abnormalities in mice: focus on Sacra gum resin.
Front Physiol
January 2024
Department of Veterinary Sciences, University of Messina, Messina, Italy.
Traumatic brain injury (TBI) is described as a structural damage or physiological disturbance of brain function that occurs after trauma and causes disability or death in people of all ages. New treatment targets for TBI are being explored because current medicines are frequently ineffectual and poorly tolerated. There is increasing evidence that following TBI, there are widespread changes in autophagy-related proteins in both experimental and clinical settings.
View Article and Find Full Text PDFNavigating role conflict: one professional's journey as a new clinician leader.
BMJ Lead
March 2024
Doctor of Physical Therapy Program, Allen College, Waterloo, Iowa, USA
Transitioning from full-time clinical work to a leadership position can be a difficult transition for healthcare professionals. Competing demands, new responsibilities and changes in how one measures success in this new role often leave new clinician-leaders feeling lost, stymied or ineffectual.Role conflict is one phenomenon which can impact a healthcare professional's transition into leadership.
View Article and Find Full Text PDFDifferential diagnosis of bone marrow failure syndromes guided by machine learning.
Blood
April 2023
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD.
The choice to postpone treatment while awaiting genetic testing can result in significant delay in definitive therapies in patients with severe pancytopenia. Conversely, the misdiagnosis of inherited bone marrow failure (BMF) can expose patients to ineffectual and expensive therapies, toxic transplant conditioning regimens, and inappropriate use of an affected family member as a stem cell donor. To predict the likelihood of patients having acquired or inherited BMF, we developed a 2-step data-driven machine-learning model using 25 clinical and laboratory variables typically recorded at the initial clinical encounter.
View Article and Find Full Text PDFImmune response after central nervous system injury.
Semin Immunol
January 2022
Department of Pathology & Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA. Electronic address:
Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide, and they can lead to severely damaging consequences such as permanent disability and paralysis. Multiple factors can obstruct recovery after CNS injury. One of the most significant is the progressive neuronal death that follows the initial mechanical impact, leading to the loss of undamaged cells via a process termed secondary neurodegeneration.
View Article and Find Full Text PDFChanges in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D.
Biomed Pharmacother
June 2022
Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; Biomedical Research Center Network in Infectious Diseases (CIBERINFEC), Spain. Electronic address:
Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may cause severe acute respiratory distress syndrome (ARDS). Vitamin D may favour an anti-inflammatory environment and improve cytotoxic response against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved in patients with COVID-19 pneumonia and levels of 25-hydroxyvitamin D (25(OH)D) of 14.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!