AI Article Synopsis
- Malaria, caused by the Plasmodium parasite, specifically Plasmodium vivax, is a widespread disease outside Africa, with around 18.9 million cases reported in 2012.
- P. vivax is difficult to study in the lab due to its inability to be cultured continuously, which has led researchers to rely on whole-genome sequencing for insights into its biology.
- Comparative genomic analysis has uncovered significant genetic diversity and new gene families in P. vivax, helping to advance our understanding of its biology and evolution, which is essential for developing future antimalarial treatments and vaccines.
Article Abstract
Malaria is a mosquito-borne disease caused by the Plasmodium parasite. Of the four Plasmodium species that routinely cause human malaria, Plasmodium vivax is the most widespread species outside Africa, causing ∼18.9 million cases in 2012. P. vivax cannot be cultured continuously in vitro, which severely hampers research in nonendemic and endemic countries alike. Consequently, whole-genome sequencing has become an effective means to interrogate the biology of the P. vivax parasite. Our comparative genomic analysis of five P. vivax reference genomes and several whole-genome sequences of the closely related monkey malaria species P. cynomolgi has revealed an extraordinary level of genetic diversity and enabled characterization of novel multigene families and important single-copy genes. The generation of whole-genome sequences from multiple clinical isolates is also driving forward knowledge concerning the biology and evolution of the species. Understanding the biology of P. vivax is crucial to develop potential antimalarial drugs and vaccines and to achieve the goal of eliminating malaria.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405435 | PMC |
| http://dx.doi.org/10.1111/nyas.12708 | DOI Listing |
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