AI Article Synopsis
- Recent advancements in reprogramming adult cells into stem cells show similarities with how cancer cells can also be reprogrammed.
- The characteristics of stem cells, such as their ability to self-renew and differentiate, align closely with the traits of cancer cells, including rapid growth and adaptability.
- The review highlights essential transcription factors related to embryonic stem cells that are often overexpressed in cancers, and explores the signaling pathways that link induced pluripotency with cancer development, emphasizing the role of the tumor suppressor p53.
Article Abstract
Rapid progress in the field of adult cells reprogramming back into a stem cell-like fate revealed shared mechanisms of action with tumoural reprogramming. A hallmark of stem cells - self-renewal and differentiation potential - seems to be tightly interlaced with large proliferation capacity and cellular plasticity of cancer cells. In this review, we briefly summarise the core transcription factors critical to maintenance of ES cell signature and overexpressed in many types of cancer, as well as signalling pathways involved in both induced pluripotency and oncogenesis, with particular regard to the role of tumour suppressor p53.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322532 | PMC |
| http://dx.doi.org/10.5114/wo.2014.47133 | DOI Listing |
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