Early development of the mammalian cerebral cortex proceeds via a sequence of proliferative and differentiative steps from neural stem cells toward neurons and glia. However, how these steps are molecularly orchestrated is still only partially understood. In this issue of The EMBO Journal, Artegiani and colleagues implicate Tox, a HMG-box transcription factor previously known only for its role in lymphocyte development, in early cortical development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388592 | PMC |
| http://dx.doi.org/10.15252/embj.201591107 | DOI Listing |
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EMBO J
April 2015
Laboratory "Adult Neurogenesis and Cellular Reprogramming", Institute of Physiological Chemistry, University Medical Center Johannes Gutenberg University Mainz, Mainz, Germany Focus Program Translational Neuroscience, Johannes Gutenberg University Mainz, Mainz, Germany.
Early development of the mammalian cerebral cortex proceeds via a sequence of proliferative and differentiative steps from neural stem cells toward neurons and glia. However, how these steps are molecularly orchestrated is still only partially understood. In this issue of The EMBO Journal, Artegiani and colleagues implicate Tox, a HMG-box transcription factor previously known only for its role in lymphocyte development, in early cortical development.
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