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Epigenetic and transcriptional determinants of the human breast. | LitMetric

Epigenetic and transcriptional determinants of the human breast.

Nat Commun

1] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3 [2] Centre for High-Throughput Biology and Department of Microbiology &Immunology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4.

Published: February 2015

AI Article Synopsis

Article Abstract

While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known about the epigenetic changes that accompany post-natal differentiation where fully functional differentiated cell types with limited lifespans arise. Here we sought to address this gap by generating epigenomic and transcriptional profiles from primary human breast cell types isolated from disease-free human subjects. From these data we define a comprehensive human breast transcriptional network, including a set of myoepithelial- and luminal epithelial-specific intronic retention events. Intersection of epigenetic states with RNA expression from distinct breast epithelium lineages demonstrates that mCpG provides a stable record of exonic and intronic usage, whereas H3K36me3 is dynamic. We find a striking asymmetry in epigenomic reprogramming between luminal and myoepithelial cell types, with the genomes of luminal cells harbouring more than twice the number of hypomethylated enhancer elements compared with myoepithelial cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346612PMC
http://dx.doi.org/10.1038/ncomms7351DOI Listing

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