During the period 1950-1970, groundbreaking research on the genetic mapping of Chlamydomonas reinhardtii and the use of mutant strains to analyze photosynthesis was conducted in the laboratory of R. Paul Levine at Harvard University. An account of this era, based in part on interviews with Levine, is presented.
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J Womens Health (Larchmt)
January 2025
Department of Orthopaedic Surgery and Rehabilitation, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
The attrition of health care professionals from institutions has historically been high, with reports of higher rates in women than men. High attrition jeopardizes the institution's financial stability, quality of patient care, and scholarly contributions to advancing health care. The disproportionate loss of women reduces the diversity of perspectives and skills needed to meet patient needs.
View Article and Find Full Text PDFNat Rev Genet
January 2025
Institute of Ecology and Evolution, University of Oregon, Eugene, OR, USA.
Traditionally, differences among individuals have been divided into genetic and environmental causes. However, both types of variation can underlie regulatory changes in gene expression - that is, epigenetic changes - that persist across cell divisions (developmental differentiation) and even across generations (transgenerational inheritance). Increasingly, epigenetic variation among individuals is recognized as an important factor in human diseases and ageing.
View Article and Find Full Text PDFSci Rep
January 2025
Faculty of Innovation and Design, City University of Macau, Macau, China.
The city's rapid development would lead to irreversible changes in architectural heritage. As one of the ways to promote sustainable development, world heritage tourism has opened up a new perspective for the protection, inheritance and development of architectural heritage. Taking the study of architectural heritage in the Historic Centre of Macau as an example, employing eye-tracking experiment and semantic differential method (SD method) to explore the relationship between tourists' perceptions of visual elements of architectural heritage, positive emotions, and behavioral intentions.
View Article and Find Full Text PDFSignal Transduct Target Ther
January 2025
Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Mitochondria are essential for cellular function and viability, serving as central hubs of metabolism and signaling. They possess various metabolic and quality control mechanisms crucial for maintaining normal cellular activities. Mitochondrial genetic disorders can arise from a wide range of mutations in either mitochondrial or nuclear DNA, which encode mitochondrial proteins or other contents.
View Article and Find Full Text PDFChin Med J (Engl)
December 2024
Cardiac Surgery, Cardiac Center, The First Hospital of Tsinghua University, Chaoyang District, Beijing 100016, China.
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