Surface characterization and cytotoxicity response of biodegradable magnesium alloys.

Mater Sci Eng C Mater Biol Appl

Mechanical Engineering Department, University of Texas Pan American, Edinburg, TX, United States. Electronic address:

Published: April 2015

AI Article Synopsis

  • Magnesium alloys are gaining popularity among researchers as third-generation materials due to their favorable biocompatibility, low density, and mechanical properties, making them strong candidates for biodegradable implants.
  • Fast and uneven corrosion in aqueous environments poses challenges for their use in orthopedic and cardiovascular applications, highlighting the need to control degradation rates for successful outcomes.
  • The study examines three magnesium alloy grades (AZ31B, AZ91E, and ZK60A) using various advanced techniques to assess their corrosion resistance, biocompatibility, and the cytotoxic effects of metal ions.

Article Abstract

Magnesium alloys have raised an immense amount of interest to many researchers because of their evolution as a new kind of third generation materials. Due to their biocompatibility, density, and mechanical properties, magnesium alloys are frequently reported as prospective biodegradable implant materials. Moreover, magnesium alloys experience a natural phenomenon to biodegrade in aqueous solutions due to its corrosion activity, which is excellent for orthopedic and cardiovascular applications. However, a major concern with such alloys is fast and non-uniform corrosion degradation. Controlling the degradation rate in the physiological environment determines the success of biodegradable implants. In this investigation, three different grades of magnesium alloys: AZ31B, AZ91E and ZK60A were studied for their corrosion resistance and biocompatibility. Scanning electron microscopy, energy dispersive spectroscopy, atomic force microscopy and contact angle meter are used to study surface morphology, chemistry, roughness and wettability, respectively. Additionally, the cytotoxicity of the leached metal ions was evaluated by using a tetrazolium based bio-assay, MTS.

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http://dx.doi.org/10.1016/j.msec.2015.01.017DOI Listing

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