Optical coherence tomography (OCT) is capable of providing quantitative and objective assessments of the optic disc, macula and retinal nerve fiber layer in glaucoma. The recent advent of spectral domain OCT (SD-OCT) has enhanced the resolution, decreased scan acquisition time, and improved the reproducibility of measurements compared to older versions of this technology. However, although OCT has been successfully used for detection of disease and evaluation of progression, the limited agreement between structural and functional tests indicates the strong need for a combined approach for detecting and monitoring the disease. A recently described approach for estimation of rates of retinal ganglion cell loss from a combination of SD-OCT and functional data is a promising method for diagnosing, staging, detecting progression, and estimating rates of glaucomatous deterioration.
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http://dx.doi.org/10.1007/s40135-013-0014-4 | DOI Listing |
Theranostics
January 2025
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Metastasis represents a stage in which the therapeutic objective changes from curing disease to prolonging survival, as detection typically occurs at advanced stages. Technologies for the early identification of disease would enable treatment at a lower disease burden and heterogeneity. Herein, we investigate the vascular dynamics within a synthetic metastatic niche as a potential marker of disease progression.
View Article and Find Full Text PDFJ Vitreoretin Dis
December 2024
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
To report a case of macular chorioretinal atrophy associated with Stickler syndrome in a pediatric patient with a genetically confirmed mutation. A single case was evaluated. A 3-year-old girl was found to have macular chorioretinal atrophy in the right eye and a retinal detachment in the left eye.
View Article and Find Full Text PDFTheranostics
January 2025
School of Pen-Tung Sah Institute of Micro-Nano Science and Technology, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Center for Molecular Imaging and Translational Medicine, Department of Vascular & Tumor Interventional Radiology, The First Affiliated Hospital of Xiamen University, School of Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
Brain diseases are a leading cause of disability and death worldwide. Early detection can lead to earlier intervention and better outcomes for patients. In recent years, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging have been widely used in stroke, traumatic brain injury (TBI), and brain cancer due to their advantages of , unlabeled, and high-resolution 3D microvessel imaging at the capillary resolution level.
View Article and Find Full Text PDFJ Res Med Sci
October 2024
Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Diabetic retinopathy (DR) is one of the complications of diabetes. This study was conducted to investigate the effect of curcumin-piperine on laboratory factors and macular vascular in DR.
Materials And Methods: The present study was a randomized, placebo-controlled, double-blind, parallel-arm clinical trial that was conducted on 60 patients with DR aged 30-65 years.
J Med Imaging (Bellingham)
January 2025
University of Arizona, College of Biomedical Engineering, Tucson, Arizona, United States.
Purpose: Diffusion magnetic resonance imaging (dMRI) quantitatively estimates brain microstructure, diffusion tractography being one clinically utilized framework. To advance such dMRI approaches, direct quantitative comparisons between microscale anisotropy and orientation are imperative. Complete backscattering Mueller matrix polarized light imaging (PLI) enables the imaging of thin and thick tissue specimens to acquire numerous optical metrics not possible through conventional transmission PLI methods.
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