Glass/silica-based flow channels are widely used in capillary electrophoresis and micro-total analysis systems. However, it is almost impossible to achieve controllable fabrication of microstructures with enhanced mixing performance for high-efficiency bio-analysis in confined micro-channels. Here, various morphologies were controllably achieved by tuning the molar ratio of the reaction agents in a confined microchannel. Fluid flow simulation is demonstrated to investigate the structure stability and mixing performance. Multifunctional networks with uniform and deep decoration are fabricated in confined micro-capillaries, owing to the enhanced mixing performance. The modified micro-capillaries exhibit high efficiencies for the selective enrichment of phosphopeptides from traditional model samples. Furthermore, the fabricated micro-capillaries also exhibited high performance in practical applications (for selective enrichments from bovine milk and cancer serum). These outstanding features make the microstructure-modified micro-capillaries promising for bio-analysis.
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| http://dx.doi.org/10.1016/j.jcis.2015.01.048 | DOI Listing |
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