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PET imaging of unruptured intracranial aneurysm inflammation (PET-IA) study: a feasibility study protocol.
BMJ Open
February 2024
Clinical Neurosciences, University of Turku, Turku, Finland.
Article Synopsis
- - The study aims to assess the feasibility of using PET imaging (specifically with 18F-FDG and 68Ga-DOTANOC tracers) to evaluate inflammation in the walls of unruptured intracranial aneurysms (UIA) prior to surgical treatment.
- - Patients scheduled for surgery will undergo a series of imaging tests and sample collections to measure the uptake of the tracers in aneurysms and relate it to various clinical and histological factors.
- - The research has received ethical approval and intends to share its findings through scientific publications and conferences, contributing to the understanding of UIA and arterial inflammation.
Dynamic contrast-enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma.
Head Neck
September 2021
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Background And Purpose: Morphological assessment with conventional magnetic resonance imaging (MRI) sequences has limited specificity to distinguish between paragangliomas and schwannomas. Assessing the differences in microvascular properties through pharmacokinetic parameters of dynamic contrast-enhanced (DCE)-MRI can provide additional information to aid in this differentiation.
Materials And Methods: A prospective study on MR characterization of neck masses was performed between January 2017 and March 2019 in our department, out of which 40 patients with head and neck paragangliomas (HNPGLs) (33 lesions) and schwannomas (15 lesions) were included in this analysis.
Ga DOTANOC PET/CT Scan in Primary Juvenile Nasopharyngeal Angiofibroma - A Pilot Study.
Laryngoscope
July 2021
Department of Otorhinolaryngology & Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Objectives/hypothesis: Somatostatin receptors (SSTRs) are highly expressed in neuroendocrine tumors and is exploited for its imaging and treatment. SSTRs expression is also demonstrated in diverse benign and malignant tumor cell types and proliferating peri-tumoral vessels. Similarly, Juvenile Nasopharyngeal Angiofibroma (JNA) expresses different SSTRs and may be utilized for its imaging and treatment using DOTA, 1-Nal3-octreotide (DOTANOC)-PET/CT scan.
View Article and Find Full Text PDFHead-to-Head Comparison of 18F-DOPA PET/CT and 68Ga-DOTANOC PET/CT in Patients With Midgut Neuroendocrine Tumors.
Clin Nucl Med
March 2021
From the Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA.
Purpose: The aim of this study was to compare retrospectively 18F-DOPA PET/CT versus 68Ga-DOTANOC PET/CT in a group of patients affected by midgut NET.
Patients And Methods: Patients with histologically proven grade 1 or grade 2 midgut NET were explored after injection of 150 MBq of 68Ga-DOTANOC and 210 MBq of 18F-DOPA. The PET/CTs were analyzed visually and semiquantitatively at the patient level, regional level (7 defined regions), and lesion level (maximum of 5 lesions/organ).
Prediction of the aggressiveness of non-functional pancreatic neuroendocrine tumors based on the dual-tracer PET/CT.
EJNMMI Res
December 2019
Division of Digestive Surgery and Urology, Turku University Hospital, P.O. Box 52, FIN-20521, Turku, Finland.
Background: Predicting the aggressive behavior of non-functional pancreatic neuroendocrine tumors (NF-PNET) remains controversial. We wanted to explore, in a prospective setting, whether the diagnostic accuracy can be improved by dual-tracer functional imaging Ga-DOTANOC and F-FDG-PET/CT in patients with NF-PNETs.
Methods: Thirty-one patients with NF-PNET (90% asymptomatic) underwent PET-imaging with F-FDG and Ga-DOTANOC, followed by surgery (n = 20), an endoscopic ultrasonography and fine-needle biopsy (n = 2) or follow-up (n = 9).
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