AI Article Synopsis
- The study investigates the relationship between the ALDH2 Glu504Lys polymorphism and cancer risk through a meta-analysis of 51 case-control studies.
- The analysis found that individuals with the Lys+ genotypes had a 20% higher overall cancer risk, with significant risks for upper aerodigestive tract (UADT) cancers and particularly higher risk in the Japanese population (38% increase).
- The conclusion suggests that this genetic variant is a key factor linked to cancer susceptibility, emphasizing its impact on specific cancer types and demographics.
Article Abstract
Background: The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk.
Methods: Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2).
Results: A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03-1.39, P = 0.02, I2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11-1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12-1.71, P = 0.003, I2 = 93%).
Conclusions: Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334541 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117173 | PLOS |
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