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Cow ghee as an efficient carrier to improve oral bioavailability of lutein.
Food Chem
September 2022
Nitte University Center for Science Education and Research (NUCSER), Nitte (Deemed to be University), Paneer Campus, Deralakatte, Mangaluru 575018, Karnataka, India. Electronic address:
In India, cow-ghee has been used in traditional medicinal preparations to solubilize lipophilic drugs and enhance intestinal absorption. However, reports exploring the role of cow-ghee, naturally rich in saturated fatty acids, in carotenoid chemistry is nil. We attempted to understand the influence of fatty-acid composition of cow-ghee and edible oils on intestinal absorption of lutein in mice.
View Article and Find Full Text PDFEmulsions containing optimum cow milk fat and canola oil mixtures replicate the lipid self-assembly of human breast milk during digestion.
J Colloid Interface Sci
April 2021
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, VIC 3052, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia. Electronic address:
Hypothesis: The digestion of different milks and milk substitutes leads to the formation of a variety of self-assembled lipid structures, with the structuring of human milk being paramount for infant nutrition. It was hypothesised that mixing cow milk fat rich in medium/long-chain lipids with canola oil rich in long-chain unsaturated lipids would replicate the structuring of human milk by balancing lipid chain lengths and saturation levels.
Experiments: Emulsions of cow milk fat/canola oil mixtures were prepared in two ways - by pre-mixing ghee and canola oil before dispersing them and by dispersing canola oil directly into commercial cow milk.
Can people-centered community-oriented interventions improve skilled birth attendance? Evidence from a quasi-experimental study in rural communities of Cambodia, Kenya, and Zambia.
BMC Pregnancy Childbirth
September 2020
World Vision International, Washington DC, USA.
Background: Skilled attendance at delivery is a key marker for reducing maternal mortality. Effective community engagement strategies complemented by community health worker (CHW) services can improve access to maternal health services in areas with limited health infrastructure or workforce.
Methods: A quasi-experimental study with matched comparison groups was conducted in Cambodia, Kenya and Zambia to determine the effect of integrated community investments on skilled birth attendance (SBA).
Can social accountability mechanisms using community scorecards improve quality of pediatric care in rural Cambodia?
Int J Qual Health Care
July 2020
Monitoring & Evaluation, Ministry Strategy and Evidence, World Vision International, 34834 Weyerhaeuser Way S, Federal Way, Washington, DC 98001, USA.
Objective: To determine the effect of social accountability strategies on pediatric quality of care.
Design And Setting: A non-randomized quasi experimental study was conducted in four districts in Cambodia and all operational public health facilities were included.
Participants: Five patients under 5 years and their caretakers were randomly selected in each facility.
Comparative evaluation of fish oil and butter oil in modulating delivery of galantamine hydrobromide to brain via intranasal route: pharmacokinetic and oxidative stress studies.
Drug Deliv Transl Res
August 2020
Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Air force Station Headquarter, Gandhinagar, Gujarat, 382355, India.
The present study investigates the role of fish oil (FO)- and butter oil (BO)-enriched microemulsion-based system of galantamine hydrobromide (GH), an anti-Alzheimer drug, for its potential role in brain permeation enhancement and neuroprotection against oxidative stress. Microemulsion (ME)-based system of GH was prepared using water phase titration. The prepared ME was characterized by several physicochemical parameters like particle size, polydispersity index, and ex vivo drug permeation.
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