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White blood cell counts: reference methodology. | LitMetric

White blood cell counts: reference methodology.

Clin Lab Med

Department of Pathology, University of New Mexico, MSC08 4640, 1 University of New Mexico, Albuquerque, NM 87131, USA.

Published: March 2015

Modern hematology laboratories use automated hematology analyzers to perform cell counts. These instruments provide accurate, precise, low-cost differential counts with fast turnaround times. Technologies commonly used include electrical impedance, radiofrequency conductivity, laser light scattering, and cytochemistry. This article reviews the principles of these methodologies and possible sources of error, provides guidance for selecting flagging criteria, and discusses novel, clinically relevant white blood cell parameters provided by new instruments, including immature granulocyte count and granularity index.

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Source
http://dx.doi.org/10.1016/j.cll.2014.10.007DOI Listing

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