In recent decades, gout became the most common inflammatory arthritis and one in which pathogenesis and risk factors are best understood. One of the treatment objectives in current guidelines is "cure". However, audits show that minority of patients with gout receive adequate advice and treatment. Doctors often focus on managing acute attacks rather than viewing gout as a chronic progressive crystal deposition disease. Accordingly, urate-lowering treatment is underprescribed and often underdosed. The recent introduction of a panel of new treatments of gout and a better understanding of epidemiologic factors (such as the fructose) may improve management of this easily diagnosed and curable form of potentially severe arthritis, worsening probably the cardiovascular prognostic.
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Nefrologia (Engl Ed)
August 2024
Serviço de Genética Médica, Centro Hospitalar Universitário de São João, Porto, Portugal; Unidade de Genética, Departamento de Patologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal; Grupo de Investigação e Desenvolvimento em Nefrologia e Doenças Infeciosas, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. Electronic address:
Joint Bone Spine
September 2024
Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Ankara, Turkey.
Sci Rep
March 2023
Chemistry Department, College of Science, King Khalid University, Abha, 61421, Saudi Arabia.
The NEK7 protein is required for spindle formation, cell division, and the activation of the NLRP3 inflammasome receptor. The aberrant expression of NEK7 has been implicated to the growth of metastasis and severe inflammatory conditions like rheumatoid arthritis, liver cirrhosis, and gout. An emergent target for the development of anti-cancer drugs is NEK7.
View Article and Find Full Text PDFClin Rheumatol
June 2022
Department of Health Statistics, Naval Medical University, Shanghai, 200433, China.
Background: The clinical outcomes of patients with rheumatic diseases infected with COVID-19 were inconsistent characteristics across regions and time periods. We need to revisit and sort out the clinical characteristics of these patients at the beginning of the global COVID-19 epidemic.
Methods: We collected data from confirmed COVID-19 patients from two military-run field hospitals and classified them into the rheumatic disease group and no rheumatic disease groups, and the latter was further distinguished by ARD and non-ARD.
Ann Pharmacother
April 2022
Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Background: The incidence and health care costs of gout flares have increased in the United States. The increased costs may be a result of a lack of adherence to treatment guidelines and medication knowledge. Identifying causes for this trend is vital to mitigate inappropriate resource use.
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