Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/15265161.2014.990763 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Article Synopsis
- Habitat fragmentation and environmental change threaten self-incompatible plant species that require high mate availability for survival, necessitating various rescue strategies.
- A study using a model over 500 years found that genetic rescue is the most effective method for enhancing fitness and viability of small plant populations, while demographic rescue also shows considerable benefits.
- Combining genetic rescue with habitat improvements provided the best outcomes, enhancing both population persistence and mate availability significantly, particularly with the addition of new genetic diversity (S alleles).
The N-terminus of the effector Tarp engages the host Hippo pathway.
bioRxiv
September 2024
Immunity and Pathogenesis Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827 USA.
is an obligate, intracellular Gram-negative bacteria and the leading bacterial STI in the United States. 's developmental cycle involves host cell entry, replication within a parasitophorous vacuole called an inclusion, and induction of host cell lysis to release new infectious particles. During development, manipulates the host cell biology using various secreted bacterial effectors.
View Article and Find Full Text PDFmodulates the expression of JAK-STAT signaling components to attenuate the type II interferon response of epithelial cells.
mBio
October 2024
Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Unlabelled: has adapted to subvert signaling in epithelial cells to ensure successful intracellular development. Interferon-γ (IFNγ) produced by recruited lymphocytes signals through the JAK/STAT pathway to restrict chlamydial growth in the genital tract. However, during infection , addition of IFNγ does not fully induce nuclear localization of its transcription factor STAT1 and expression of its target gene, IDO1.
View Article and Find Full Text PDFOpt-out vaccination in school and daycare: Reconciling parental authority and obligations.
Bioethics
November 2024
Department of Political Science and Centre for the Experimental-Philosophical Study of Discrimination (CEPDISC), Aarhus University, Aarhus, Denmark.
Article Synopsis
- There is a growing trend of vaccine hesitancy among parents, leading to lower immunization rates and prompting a need to rethink childhood vaccination approaches.
- Parents' decisions about vaccinating their children are heavily affected by cognitive biases, which can be leveraged to boost vaccination rates by altering how choices are presented.
- Implementing opt-out vaccination programs in schools or daycare respects parental authority while promoting the moral responsibility most parents feel to vaccinate their kids.
SGLT2 inhibitors activate pantothenate kinase in the human heart.
bioRxiv
July 2024
Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant pharmacologic target of SGLT2i remains unclear. We show here that SGLT2i directly activate pantothenate kinase 1 (PANK1), the rate-limiting enzyme that initiates the conversion of pantothenate (vitamin B5) to coenzyme-A (CoA), an obligate co-factor for all major pathways of fuel use in the heart.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!