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Comparison of two medications in central nervous system toxoplasmosis in patients with AIDS.
Ital J Neurol Sci
September 1992
Istituto di Clinica delle Malattie Infettive, Università Cattolica del Sacro Cuore, Roma.
Article Synopsis
- A study involving 39 AIDS patients with central nervous system toxoplasmosis assessed the effectiveness and safety of two drug combinations: pyrimethamine-sulfadiazine and pyrimethamine-clindamycin.
- The pyrimethamine-sulfadiazine combination yielded a 79% response rate, while the clindamycin combination had a high failure rate.
- Although there were more side effects reported with sulfadiazine, the use of desensitization protocols helped minimize treatment discontinuations, establishing pyrimethamine-sulfadiazine as the preferred therapy for this condition in AIDS patients, with further research needed on alternative treatments.
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