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Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics. | LitMetric

AI Article Synopsis

  • The neonatal Fc receptor (FcRn) is crucial for transporting maternal antibodies (IgG) to the fetus and protecting them from degradation inside cells.
  • FcRn also binds to albumin and helps regulate its levels, alongside IgG, within various body tissues.
  • Understanding how FcRn interacts with these proteins is important for drug development, especially for therapies that utilize IgG and albumin.

Article Abstract

The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for protecting IgG from intracellular catabolism. However, it has now become apparent that the same receptor also binds albumin and plays a fundamental role in homeostatic regulation of both IgG and albumin, as FcRn is expressed in many different cell types and organs at diverse body sites. Thus, to gain a complete understanding of the biological function of each ligand, and also their distribution in the body, an in-depth characterization of how FcRn binds and regulates the transport of both ligands is necessary. Importantly, such knowledge is also relevant when developing new drugs, as IgG and albumin are increasingly utilized in therapy. This review discusses our current structural and biological understanding of the relationship between FcRn and its ligands, with a particular focus on albumin and design of albumin-based therapeutics.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306297PMC
http://dx.doi.org/10.3389/fimmu.2014.00682DOI Listing

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