AI Article Synopsis
- Infections are a significant concern for children undergoing treatment for acute lymphoblastic leukemia (ALL), impacting their health during therapy.
- A study of 256 children revealed 65 cases of infectious complications, primarily during the 15th day of treatment, with neutropenia commonly accompanying these infections.
- Despite these challenges, the study found a low infection rate and favorable outcomes for patients, suggesting that infections did not negatively impact treatment response or overall patient prognosis.
Article Abstract
Background: Infections remain a major cause of therapy-associated morbidity and mortality in children with acute lymphoblastic leukemia (ALL).
Methods: We retrospectively analyzed the medical charts of 256 children treated for ALL under the CCLG-2008 protocol in Beijing Children's Hospital.
Results: There were 65 infectious complications in 50 patients during vincristine, daunorubicin, L-asparaginase and dexamethasone induction therapy, including microbiologically documented infections (n = 12; 18.5%), clinically documented infections (n = 23; 35.3%) and fever of unknown origin (n = 30; 46.2%). Neutropenia was present in 83.1% of the infectious episodes. In all, most infections occurred around the 15 th day of induction treatment (n = 28), and no patients died of infection-associated complications.
Conclusions: The infections in this study was independent of treatment response, minimal residual diseases at the end of induction therapy, gender, immunophenotype, infection at first visit, risk stratification at diagnosis, unfavorable karyotypes at diagnosis and morphologic type. The infection rate of CCLG-2008 induction therapy is low, and the outcome of patients is favorable.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836249 | PMC |
| http://dx.doi.org/10.4103/0366-6999.151085 | DOI Listing |
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