Synthesis of Vinyl Trifluoromethyl Thioethers via Copper-Mediated Trifluoromethylthiolation of Vinyl Bromides.

A copper-mediated trifluoromethylthiolation of vinyl bromides has been developed. This method provides ready access to vinyl trifluoromethyl thioethers in good to high yields from simple, inexpensive starting materials. A broad substrate scope is achieved, and the reaction is compatible with various functional groups, including cyano, nitro, trifluoromethyl, alkoxy, amino, halide, and heterocyclic groups.