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Background: The International Agency for Research on Cancer recently classified diesel engine exhaust (DEE) as a Group I carcinogen based largely on its association with lung cancer. However, the exposure-response relationship is still a subject of debate and the underlying mechanism by which DEE causes lung cancer in humans is not well understood.
Methods: We conducted a cross-sectional molecular epidemiology study in a diesel engine truck testing facility of 54 workers exposed to a wide range of DEE (ie, elemental carbon air levels, median range: 49.7, 6.1-107.7 µg/m(3)) and 55 unexposed comparable controls.
Results: The total lymphocyte count (p=0.00044) and three of the four major lymphocyte subsets (ie, CD4+ T cells (p=0.00019), CD8+ T cells (p=0.0058) and B cells (p=0.017)) were higher in exposed versus control workers and findings were highly consistent when stratified by smoking status. In addition, there was evidence of an exposure-response relationship between elemental carbon and these end points (ptrends<0.05), and CD4+ T cell levels were significantly higher in the lowest tertile of DEE exposed workers compared to controls (p=0.012).
Conclusions: Our results suggest that DEE exposure is associated with higher levels of cells that play a key role in the inflammatory process, which is increasingly being recognised as contributing to the aetiology of lung cancer.
Impact: This study provides new insights into the underlying mechanism of DEE carcinogenicity.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438624 | PMC |
http://dx.doi.org/10.1136/oemed-2014-102556 | DOI Listing |
Heliyon
December 2024
Faculty of Transportation Engineering, Ho Chi Minh City University of Technology (HCMUT), Ho Chi Minh City, Viet Nam.
The drivetrain is an essential component of the diesel firefighting pump system, affecting the engine's operating mode, power, economy, and environment. This study proposes a process to design and optimize the transmission ratio and working load of the diesel firefighting pump system. AVL BOOST software was used to model the 6-cylinder diesel engine and analyze the performance characteristics at its partial loads as parameters for finding the optimal transmission ratio of the drivetrain.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Electrical Engineering, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran.
Considering the widespread use of PHEVs in advanced societies and the issues ahead, researchers' thinking has focused more on this issue. The important issue is that the use of EVs is increasing due to the advantages, but the necessary infrastructure for their charging stations in the distribution networks does not exist. The high penetration level of EVs can create a potential risk for the existing distribution network; the fair charging of EVs has a special value.
View Article and Find Full Text PDFACS Omega
December 2024
College of Energy Engineering, Zhejiang University, Hangzhou 310027, PR China.
Nano-AlO derived from recyclable sources emerges as a promising sustainable solution for enhancing diesel engine efficiency while mitigating emissions. However, a lack of an in-depth understanding of the health hazard aspect still challenges its commercial applications. To this end, nano-AlO/diesel (NAD) blends prepared via ultrasonic homogenization were experimentally and analytically investigated under various injection timings and excess air coefficients to explore the potential of nano-AlO for balancing energy performance and emissions.
View Article and Find Full Text PDFSci Total Environ
December 2024
Department of Public Health Sciences, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA; Institute for a Sustainable Environment, Clarkson University, Potsdam, NY, USA.
Advanced receptor models can leverage the information derived from optical and chemical variables as input by a variety of instruments at different time resolutions to extract the source specific absorption Ångström exponent (AAE) from aerosol absorption. The multilinear engine (ME-2), a Positive Matrix Factorization (PMF) solver, serves as a proficient tool for performing such analyses, thereby overcoming the constraints imposed by the assumptions in current optical source apportionment methods such as the Aethalometer approach since the use of a-priori AAE values introduces additional uncertainty into the results of optical methods. Comprehensive PM chemical speciation datasets, and aerosol absorption coefficients (b, λ) at seven wavelengths measured by an Aethalometer (AE33), were used in multi-time source apportionment (MT-PMF).
View Article and Find Full Text PDFSci Total Environ
December 2024
ASEM (Czech Association of Emissions Technicians), Boleslavská 902, 293 06 Kosmonosy, Czech Republic.
This work investigates the detection of defunct or absent diesel particle filters by drive-through remote sensing measurement at the Czech University of Life Sciences main vehicular entrance gate. An exhaust sample was collected by a line attached to the road surface in the center of the travel lane. A non-volatile particle number (nvPN) counter and electric mobility particle size classifier were used to measure particle number concentrations, and an FTIR analyzer was used to measure CO, CO, and NO concentrations.
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