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Trans, Trans-Farnesol Enhances the Anti-Bacterial and Anti-Biofilm Effect of Arachidonic Acid on the Cariogenic Bacteria and .
Int J Mol Sci
November 2024
Institute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem Campus, Jerusalem 9112102, Israel.
Background: and are Gram-positive bacteria involved in the development of dental caries, as they are able to form biofilms on tooth enamel, ferment sugars into acids, and survive under acidic conditions. This ultimately leads to a local lowering of the pH value on the tooth surface, which causes enamel cavities.
Hypothesis: One measure to reduce caries is to limit the growth of cariogenic bacteria by using two anti-bacterial agents with different mechanisms of action.
Metabolomic Analysis of Histological Composition Variability of High-Grade Serous Ovarian Cancer Using H HR MAS NMR Spectroscopy.
Int J Mol Sci
October 2024
Department of Medical Physics, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.
In this work, the HR MAS NMR (high-resolution magic-angle spinning nuclear magnetic resonance) spectroscopy technique was combined with standard histological examinations to investigate the metabolic features of high-grade serous ovarian cancer (HGSOC) with a special focus on the relation between a metabolic profile and a cancer cell fraction. The studied group consisted of 44 patients with HGSOC and 18 patients with benign ovarian tumors. Normal ovarian tissue was also excised from 13 control patients.
View Article and Find Full Text PDFReversibly Crosslinked Polyurethane Fibres from Sugar-Based 5-Chloromethylfurfural: Synthesis, Fibre-Spinning and Fibre-to-Fibre Recycling.
ChemSusChem
October 2024
Department of Chemistry, Centre for Analysis and Synthesis, Lund University, SE-221 00, Lund, Sweden.
The development of recyclable crosslinked thermosetting fibres is a challenging research topic. In the present work, we have designed and synthesized polyurethane fibres from fructose-derived 5-chloromethylfurfural (CMF) and lignin-derived monomeric phenols. The greenhouse gas emissions associated with the production of CMF showed comparable results to that of 5-hydroxymethylfurfural (HMF), a high potential sugar-based platform molecule.
View Article and Find Full Text PDFElucidating microRNA-34a organisation within human Argonaute-2 by dynamic nuclear polarisation-enhanced magic angle spinning NMR.
Nucleic Acids Res
October 2024
Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, 75237 Uppsala, Sweden.
Understanding mRNA regulation by microRNA (miR) relies on the structural understanding of the RNA-induced silencing complex (RISC). Here, we elucidate the structural organisation of miR-34a, which is de-regulated in various cancers, in human Argonaute-2 (hAgo2), the effector protein in RISC. This analysis employs guanosine-specific isotopic labelling and dynamic nuclear polarisation (DNP)-enhanced Magic Angle Spinning (MAS) NMR.
View Article and Find Full Text PDFPancreatic islet cells in microfluidic-spun hydrogel microfibers for the treatment of diabetes.
Acta Biomater
October 2024
Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China; Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Southeast University, Nanjing 210009, China. Electronic address:
Islet transplantation has been developed as an effective cell therapy strategy to treat the progressive life-threatening disease Type 1 diabetes (T1DM). To mimic the natural islets and achieve immune isolation, hydrogel encapsulation of multiple islet cell types is the current endeavor. Here, we present a microfiber loading with pancreatic α and β cells by microfluidic spinning for diabetes treatment.
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