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First noninvasive thermal ablation of a brain tumor with MR-guided focused ultrasound. | LitMetric

AI Article Synopsis

  • Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a precise technique for noninvasive thermal ablation of target tissues, increasingly used for extracranial tumors but just gaining recognition for brain surgeries.
  • The technique has shown particular promise in functional neurosurgery, while its use for tumor treatment has faced delays due to technical challenges.
  • A case study involving a 63-year-old patient with recurrent glioblastoma demonstrated successful partial tumor ablation using transcranial MRgFUS, marking a significant step in proving the procedure's safety and feasibility for brain tumor treatment.

Article Abstract

Magnetic resonance-guided focused ultrasound surgery (MRgFUS) allows for precise thermal ablation of target tissues. While this emerging modality is increasingly used for the treatment of various types of extracranial soft tissue tumors, it has only recently been acknowledged as a modality for noninvasive neurosurgery. MRgFUS has been particularly successful for functional neurosurgery, whereas its clinical application for tumor neurosurgery has been delayed for various technical and procedural reasons. Here, we report the case of a 63-year-old patient presenting with a centrally located recurrent glioblastoma who was included in our ongoing clinical phase I study aimed at evaluating the feasibility and safety of transcranial MRgFUS for brain tumor ablation. Applying 25 high-power sonications under MR imaging guidance, partial tumor ablation could be achieved without provoking neurological deficits or other adverse effects in the patient. This proves, for the first time, the feasibility of using transcranial MR-guided focused ultrasound to safely ablate substantial volumes of brain tumor tissue.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322509PMC
http://dx.doi.org/10.1186/2050-5736-2-17DOI Listing

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