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Structural characterization of complex tannins from Euryale ferox fruit peels and their inhibitory mechanisms against tyrosinase activity and melanogenesis.
Int J Biol Macromol
January 2025
College of Life Science, Yangtze University, Jingzhou, China. Electronic address:
Tyrosinase is a rate-limiting enzyme for melanogenesis and abnormal melanin production can be controlled by utilizing tyrosinase inhibitory substances. To develop potent and safe inhibitors of tyrosinase, complex tannins a narrowly distributed plant polyphenols were prepared from the fruit peel of Euryale ferox (EPTs) and then structurally characterized, as well as investigated for their inhibitory effects and the involved mechanisms against tyrosinase activity and melanogenesis. The structures of EPTs were established to consist of 63.
View Article and Find Full Text PDFDevelopment of chitosan-based films with invertase enzyme for active packaging: Physicochemical parameters, structure, application, and storage.
Int J Biol Macromol
January 2025
Department of Food Science, Federal University of Lavras (UFLA), Lavras 37200-000, Brazil.
The use of active packaging made from biodegradable polymers can contribute to the environment and to the food industry by increasing the shelf life of their products. This study aimed to produce chitosan-based films incorporated with the invertase enzyme (1, 2, 5, 9, and 10 %) as an alternative to avoid sucrose crystallization in the confectionery industry. The optimum activity of the invertase enzyme was observed at 55 °C and pH 5, thus, the films made with the film-forming solution adjusted to pH 5 and dried at 55 °C were compared with those without pH adjustment and dried at room temperature.
View Article and Find Full Text PDFCrystal structure of the anti-CRISPR protein AcrIE7.
Biochem Biophys Res Commun
January 2025
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China; Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. Electronic address:
Bacterial adaptive immunity, driven by CRISPR-Cas systems, protects against foreign nucleic acids from mobile genetic elements (MGEs), like bacteriophages. The type I-E CRISPR-Cas system employs the Cascade (CRISPR-associated complex for antiviral defense) complex for target DNA cleavage, guided by crRNA. Anti-CRISPR (Acr) proteins, such as AcrIE7, counteract this defense by inhibiting Cascade activity.
View Article and Find Full Text PDFPhosphorus addition diminishes the negative effect of nitrogen addition on methane sink in subtropical forest soils.
Sci Total Environ
January 2025
Zhejiang Tiantong Forest Ecosystem National Observation and Research Station, Zhejiang Zhoushan Island Ecosystem Observation and Research Station, Institute of Eco-Chongming, School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, China. Electronic address:
Increased global nitrogen (N) and phosphorus (P) inputs caused by human activities can significantly impact methane (CH) uptake in terrestrial ecosystems. Forest soils, as the largest CH sink among terrestrial ecosystems, play a crucial role in mitigating global warming. However, the effects of long-term N and P additions on CH sink and the associated microbial mechanisms in subtropical forest soils remain unclear.
View Article and Find Full Text PDFCurrent strategies in design and synthesis of antifungals hybrid and chimeric diazine derivatives.
Bioorg Med Chem
January 2025
Alexandru Ioan Cuza University of Iasi, Faculty of Chemistry, Bd. Carol 11, 700506 Iasi, Romania. Electronic address:
In the last decades fungal infections became a major threat to human health having an unacceptably occurrence, a high rate of mortality and the number of patients at risk for these infections continue to increase every year. An effective, modern and very useful strategy in antifungal therapy is represented by the use of chimeric and hybrid drugs, most of them being with azaheterocycle skeleton. In this review, we present an overview from the last five years of the most representative achievements in the field of chimeric and hybrid diazine derivatives with antifungal properties.
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