Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5694/mja14.01525 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis and Biological Evaluation of 5'-Deoxy-adenosine Derivatives as A Adenosine Receptor Ligands.
ACS Med Chem Lett
January 2025
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
The A Adenosine Receptor (AAR) is an important therapeutic target due to its role in inflammation and immune response regulation. Herein, we synthesized and evaluated 5'-deoxy-adenosine derivatives with oxygen at the 4'-position, comparing them to previously studied 4'-thionucleosides. Compound exhibited the highest binding affinity ( = 5.
View Article and Find Full Text PDFProjections of Public Spending on Pharmaceuticals: A Review of Methods.
Pharmacoeconomics
January 2025
Belgian Health Care Knowledge Centre, Brussels, Belgium.
Background: Forecasting future public pharmaceutical expenditure is a challenge for healthcare payers, particularly owing to the unpredictability of new market introductions and their economic impact. No best-practice forecasting methods have been established so far. The literature distinguishes between the top-down approach, based on historical trends, and the bottom-up approach, using a combination of historical and horizon scanning data.
View Article and Find Full Text PDFIntegrated Network Pharmacology and Metabolomics to Investigate the Effects and Possible Mechanisms of Ginsenoside Rg Glycine Ester Derivative Against Hypoxia.
Biomed Chromatogr
February 2025
School of Pharmaceutical Sciences, Jilin University, Changchun, People's Republic of China.
Previous studies have suggested that ginsenoside Rg glycine ester derivative (RG) exhibits therapeutic potential in mitigating hypoxia. This study aimed to elucidate the potential mechanism of RG in hypoxia injury through a combined approach of metabolomics and network pharmacology. Initially, a CoCl-induced cell hypoxia model was established, and the therapeutic impact of RG on biochemical indices was evaluated.
View Article and Find Full Text PDFHistory of Lens Care Products in Japan: Insights From Advertisements in the Journal of the Japan Contact Lens Society for 65 Years.
Eye Contact Lens
December 2024
Department of Ophthalmology (H.T.), Juntendo University Shizuoka Hospital, Izunokuni, Japan; Department of Ophthalmology (A.M.), St. Marianna University School of Medicine, Kawasaki, Japan; Department of Innovative Visual Science (S.K.), Osaka University Graduate School of Medicine, Osaka, Japan; Department of Ophthalmology (Y.H.), Toho University Faculty of Medicine, Tokyo, Japan; and Japan Contact Lens Society (H.T., A.M., S.K., Y.H.), Osaka, Japan.
This review examines the history of contact lens (CL) care products, particularly focusing on hard contact lenses (HCLs) like those made from polymethyl methacrylate and rigid gas permeable (RGP) materials. Although literature on CL history is extensive, there is limited information on the history of CL care products, especially in Japan. This review uses advertisements from the Journal of the Japan Contact Lens Society from 1959 to 2023 to trace the evolution of these products.
View Article and Find Full Text PDFComparing efficacy and safety of transanal vs. laparoscopic total mesorectal excision for middle and low rectal cancer: Updated meta-analysis.
Eur J Surg Oncol
December 2024
Department of Computer Application, Guizhou University of Commerce, Guiyang, China. Electronic address:
Objective: This study aimed to compare the efficacy and safety of transanal total mesorectal excision (TaTME) with laparoscopic total mesorectal excision (LaTME) in patients with middle and low rectal cancer.
Methods: A comprehensive search of PubMed, Embase, and Cochrane databases was conducted to identify studies evaluating TaTME and LaTME from inception to June 2023. An additional search update was conducted in November 2024 to capture recently published studies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!