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Domino Partial Heart Transplantation.
Am J Transplant
December 2024
Department of Cardiovascular Surgery, Arkansas Children's Hospital, Little Rock, Arkansas. Electronic address:
Heart valve replacement in pediatric cardiothoracic surgery poses problems because conventional heart valve implants do not have the ability to grow. This mandates serial reoperations for implant exchanges until an adult size implant can fit. Partial heart transplantation eliminates these reoperations because the transplanted valves grow.
View Article and Find Full Text PDFThe persistent pool of HIV-1-infected cells is formed episodically during untreated infection.
J Virol
December 2024
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Previous studies have shown that the majority of long-lived cells harboring persistent HIV-1 proviral genomes originates from viruses circulating in the year prior to antiretroviral therapy (ART) initiation, but a smaller proportion originates from viruses circulating much earlier in untreated infection. These observations suggest that discrete biological factors influence the entry and persistence of viruses into the persistent proviral pool, and there may be periods earlier in untreated infection with increased seeding. Therefore, we examined the timing of formation of the long-lived pool of infected cells that persists during ART in seven women (after a median of 5.
View Article and Find Full Text PDFImpact on clinical guideline adherence of Orient-COVID, a clinical decision support system based on dynamic decision trees for COVID19 management: A randomized simulation trial with medical trainees.
Int J Med Inform
December 2024
INSERM, Université Sorbonne Paris Nord, Sorbonne Université, LIMICS, 75006 Paris, France. Electronic address:
Background: The adherence of clinicians to clinical practice guidelines is known to be low, including for the management of COVID-19, due to their difficult use at the point of care and their complexity. Clinical decision support systems have been proposed to implement guidelines and improve adherence. One approach is to permit the navigation inside the recommendations, presented as a decision tree, but the size of the tree often limits this approach and may cause erroneous navigation, especially when it does not fit in a single screen.
View Article and Find Full Text PDFDesign of semi-open prosthetic socket with constant force for lower limb.
Prosthet Orthot Int
December 2024
School of Intelligent Rehabilitation Engineering, Institute of Rehabilitation Engineering and Technology, University of Shanghai for Science and Technology, Shanghai, China.
Background: Prosthetic socket is a key component of the prosthesis for clinical application; its performance directly affects the adaptation of the residual limb to the prosthetic socket. There are long-term and short-term volume fluctuation of the residual limb. The volume fluctuation of the residual limb will lead to the pressure mismatch at the interface of the residual limb and the prosthetic socket, which will cause a series of skin and fit problems.
View Article and Find Full Text PDFTrue Dynamics of Pillararene Host-Guest Binding.
J Chem Theory Comput
December 2024
Changping Laboratory, No. 28 Life Science Park Rd., Beijing 102206, China.
Accurate modeling of host-guest systems is challenging in modern computational chemistry. It requires intermolecular interaction patterns to be correctly described and, more importantly, the dynamic behaviors of macrocyclic hosts to be accurately modeled. Pillar[]arenes as a crucial family of macrocycles play a critical role in host-guest chemistry and biomedical applications.
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