Two new tirucallane-type triterpenoids were isolated from the bark of Entandrophragma congoënse (Meliaceae) along with five known compounds gladoral A, bipendensin, 4-hydroxymethyl-3,5-dimethyldihydrofuran-2(3H)-one, scopoletin and 5,7-dimethoxy-6-hydroxycoumarin. Their structures were elucidated by means of spectroscopic analyses including 1D and 2D-NMR spectroscopy, high resolution mass spectrometric data as well as the comparison of data with those reported in the literature. The tested compounds (1-4) displayed moderated antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum strain NF54 and low cytotoxicity on L6 cell lines. All the isolated compounds are reported for the first time from the genus Entandrophragma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fitote.2015.01.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ethnobotanical study and vulnerability of medicinal plants used against the symptoms of COVID-19 in the Lomié subdivision, East Region of Cameroon.
Heliyon
April 2024
Department of Plant Biology, Research Unit in Forest Ecology, University of Yaoundé I, Yaoundé, PO BOX 812, Cameroon.
Science has advanced to the point that traditional medicine is now a useful instrument for treating a wide range of human ailments. Indigenous peoples and local communities (IPLCs) do not, however, have access to the contemporary healthcare system. As a result, they turn to biological resources, which are the only readily available and accessible means of treating diseases like COVID-19 and flu outbreaks.
View Article and Find Full Text PDFFormulation of into an Herbal Emulgel for the Management of Inflammation.
Gels
December 2023
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin 240101, Nigeria.
Globally, the incidence of inflammation and inflammatory disorders has continued to rise at an alarming rate. is a species of flowering plant widely distributed in Africa and has been used for the management of sickle cell disease, rheumatism, ocular inflammation, duodenal and stomach ulcers. This research aims to formulate and evaluate an anti-inflammatory herbal emulgel using an extract from stem bark (EUB).
View Article and Find Full Text PDFChemical constituents of Entandrophragma angolense and their anti-inflammatory activity.
Phytochemistry
September 2022
Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States. Electronic address:
Article Synopsis
- Researchers isolated six new compounds from the stem bark of Entandrophragma angolense, including unique triterpenoids and a catechin glucoside, alongside nineteen known compounds.
- The structure of these compounds was identified using spectroscopic methods and high-resolution mass spectrometry, with their configurations confirmed through electronic circular dichroism.
- The new compounds were tested for their ability to inhibit nitric oxide production in response to lipopolysaccharides, finding moluccensin O and (-)-catechin to have effective concentrations of 81 μM and 137 μM, respectively.
The Ethnobotany and Chemistry of South African Meliaceae: A Review.
Plants (Basel)
August 2021
Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South Africa.
Article Synopsis
- * Eight of these species have documented medicinal uses, targeting 85 different ailments, primarily gastrointestinal issues, and also including gynecological problems.
- * The chemical analysis reveals that limonoids are the major compounds in these plants, with roots and bark being the most commonly used parts, although their harvesting can be destructive, highlighting the need for research on more sustainable parts like leaves and fruits.
Triterpenoids from the bark of .
Nat Prod Res
January 2023
Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, VNUHCM-University of Science (HCMUS), Ho Chi Minh City, Vietnam.
Two new triterpenoids, entanolide () and methyl 3,4-secotirucalla-23-oxo-4(28),7,24-trien-21-al-3-oate (), together with nine known compounds (), were isolated from the bark of . Their structures were elucidated based on spectroscopic analyses, mainly 1 D and 2 D NMR spectral data. Compounds - and were evaluated for their cytotoxicity against HepG2 cells, and compounds exhibited weak activities.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!