AI Article Synopsis
- A multiple sclerosis (MS) ontology was developed to extract relevant information from scientific literature and electronic medical records (EMR) using a specialized text-mining tool called SCAIView.
- The ontology was created by reviewing literature and integrating various dictionaries, leading to the identification of drug usage and comorbidities in a study of 624 MS patients.
- Validated results indicated the ontology effectively retrieved significant genetic information related to MS and enhanced understanding of treatment pathways and patient data, showcasing its potential for improving MS research and clinical insights.
Article Abstract
Background: In order to retrieve useful information from scientific literature and electronic medical records (EMR) we developed an ontology specific for Multiple Sclerosis (MS).
Methods: The MS Ontology was created using scientific literature and expert review under the Protégé OWL environment. We developed a dictionary with semantic synonyms and translations to different languages for mining EMR. The MS Ontology was integrated with other ontologies and dictionaries (diseases/comorbidities, gene/protein, pathways, drug) into the text-mining tool SCAIView. We analyzed the EMRs from 624 patients with MS using the MS ontology dictionary in order to identify drug usage and comorbidities in MS. Testing competency questions and functional evaluation using F statistics further validated the usefulness of MS ontology.
Results: Validation of the lexicalized ontology by means of named entity recognition-based methods showed an adequate performance (F score = 0.73). The MS Ontology retrieved 80% of the genes associated with MS from scientific abstracts and identified additional pathways targeted by approved disease-modifying drugs (e.g. apoptosis pathways associated with mitoxantrone, rituximab and fingolimod). The analysis of the EMR from patients with MS identified current usage of disease modifying drugs and symptomatic therapy as well as comorbidities, which are in agreement with recent reports.
Conclusion: The MS Ontology provides a semantic framework that is able to automatically extract information from both scientific literature and EMR from patients with MS, revealing new pathogenesis insights as well as new clinical information.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321837 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116718 | PLOS |
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