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Intracerebral haemorrhage - mechanisms, diagnosis and prospects for treatment and prevention.
Nat Rev Neurol
December 2024
Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, UK.
Intracerebral haemorrhage (ICH) is a devastating condition associated with high mortality and substantial residual disability among survivors. Effective treatments for the acute stages of ICH are limited. However, promising findings from randomized trials of therapeutic strategies, including acute care bundles that target anticoagulation therapies, blood pressure control and other physiological parameters, and trials of minimally invasive neurosurgical procedures have led to renewed optimism that patient outcomes can be improved.
View Article and Find Full Text PDFIncreased incidence of ischemic stroke in young: A population-based stroke registry study from 2008 to 2018.
Rev Neurol (Paris)
October 2023
Service de Neurologie, CHRU Cavale-Blanche, Brest, France; Université Brest, Inserm, EFS, UMR 1078, GGB, 29200 Brest, France. Electronic address:
Article Synopsis
- The study analyzed stroke trends in patients under 60 in Brest from 2008 to 2018, concluding that despite a general decrease in incidence among older adults, young people experienced a rising trend in ischemic strokes.
- Among the young demographic, significant risk factors included smoking, hypertension, high-alcohol intake, and dyslipidemia.
- The diagnostic approach predominantly included brain imaging and cardiac monitoring, with a notable portion of ischemic strokes being classified as cryptogenic.
From guidelines to clinical practice in care for ischaemic stroke patients: A systematic review and expert opinion.
Eur J Neurol
December 2024
Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Leuven, Belgium.
Background And Purpose: Guidelines help physicians to provide optimal care for stroke patients, but implementation is challenging due to the quantity of recommendations. Therefore a practical overview related to applicability of recommendations can be of assistance.
Methods: A systematic review was performed on ischaemic stroke guidelines published in scientific journals, covering the whole acute care process for patients with ischaemic stroke.
Lipid control and stroke risk in atrial fibrillation patients treated with direct oral anticoagulants and statins.
Eur Stroke J
August 2024
Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Introduction: The risk of ischemic stroke and intracerebral hemorrhage (ICH) with intensive lipid control by statins among patients with atrial fibrillation (AF) who require direct oral anticoagulants (DOAC) is unclear. We aimed to determine the risks of ischemic stroke and ICH in AF patients treated with DOAC and statins.
Patients And Methods: In a population-based retrospective cohort study, we identified AF patients concurrently on DOAC and statins from 2015 to 2021 in Hong Kong.
Simvastatin alleviates glymphatic system damage via the VEGF-C/VEGFR3/PI3K-Akt pathway after experimental intracerebral hemorrhage.
Brain Res Bull
October 2024
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address:
Current clinical practice primarily relies on surgical intervention to remove hematomas in patients with intracerebral hemorrhage (ICH), given the lack of effective drug therapies. Previous research indicates that simvastatin (SIM) may enhance hematoma absorption and resolution in the acute phase of ICH, though the precise mechanisms remain unclear. Recent findings have highlighted the glymphatic system (GS) as a crucial component in intracranial cerebrospinal fluid circulation, playing a significant role in hematoma clearance post-ICH.
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