AI Article Synopsis

  • - The study investigates the role of the rostral anterior cingulate cortex (rACC) in individuals with obsessive-compulsive disorder (OCD) using fMRI and (1)H-MRS technology to assess brain function and chemical composition.
  • - Findings reveal that participants with OCD show reduced deactivation of the rACC when responding to OCD-specific words, compared to those without OCD, indicating a potential dysfunction in this brain region.
  • - However, the study found no significant differences in the levels of glutamine/glutamate (Gln/Glu) or individual glutamate and glutamine levels between the OCD and non-OCD groups, suggesting that the rACC dysfunction may not be linked to abnormal neurotransmitter activity.

Article Abstract

The anterior cingulate cortex is implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, few studies have examined functional and neurochemical abnormalities specifically in the rostral subdivision of the ACC (rACC) in OCD patients. We used functional magnetic resonance imaging (fMRI) during an emotional counting Stroop task and single-voxel J-resolved proton magnetic resonance spectroscopy ((1)H-MRS) in the rACC to examine the function and neurochemistry of the rACC in individuals with OCD and comparison individuals without OCD. Between-group differences in rACC activation and glutamine/glutamate ratio (Gln/Glu), Glu, and Gln levels, as well as associations between rACC activation, Gln/Glu, Glu, Gln, behavioral, and clinical measures were examined using linear regression. In a sample of 30 participants with OCD and 29 age- and sex-matched participants without OCD, participants with OCD displayed significantly reduced rACC deactivation compared with those without OCD in response to OCD-specific words versus neutral words on the emotional counting Stroop task. However, Gln/Glu, Glu, and Gln in the rACC did not differ between groups nor was there an association between reduced rACC deactivation and Gln/Glu, Glu, or Gln in the OCD group. Taken together, these findings strengthen the evidence for rACC dysfunction in OCD, but weigh against an underlying association with abnormal rACC glutamatergic neurotransmission.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839510PMC
http://dx.doi.org/10.1038/npp.2015.36DOI Listing

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