AI Article Synopsis
- The study focuses on validating a method to measure the elastic modulus (E) in soft biological materials (E < 5 MPa), which is crucial for understanding tissue properties and diagnosing tumors.
- Recent findings suggest that changes in cell elasticity can indicate the metastatic potential of tumors, making reliable E measurements essential.
- A robust method was developed that achieved a reproducibility limit of 4% in measuring E using thick standard samples, enhancing diagnostic sensitivity for cancer detection in biological samples.
Article Abstract
The validation of the AFM method for elastic modulus E measurement in soft materials (E <5 MPa) is still missing. The interest of measurements in materials with E <5 MPa is mainly biological, including soft tissues and single cells. For the diagnosis of malignant human tumors, a change in cell elasticity, within tissues, has recently been recognized as a marker of metastatic potential. To measure a cell elasticity difference, reproducible E measurements in biological samples are needed. In this work a robust method for a metrological validation of E measurements in the range 500-5000 kPa was developed, based on the realization of thick E standard samples and on the study of the interactions between the measurement process and the sample at micro- and nano-scale. E measurement reproducibility limit of 4% has been reached. This allows designing a very sensitive and reproducible measurement of E in biological samples representing thus a powerful diagnostic tool for cancer detection.
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| http://dx.doi.org/10.1016/j.jbiomech.2015.01.023 | DOI Listing |
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