We give descriptions of three new Fridericia species (Enchytraeidae, Oligochaeta) from Transylvania, Romania. Fridericia transylvanica sp. n. is a large-sized worm with a maximum of 4 chaetae per bundle. The spermathecae are separate entally and have two sac-like diverticula bent distad with the ampulla forming a common U-shaped sperm-containing chamber. The species was found not only in the Transylvanian Plateau but also in different regions of the Carpathians in Romania and Serbia. Fridericia gyromonodactyla sp. n. is medium-sized with a maximum of 3 chaetae per bundle. There are only four pairs of preclitellar nephridia. The spermathecal ectal duct is contractile and shorter than the body diameter; each ampulla has only one diverticulum, elongate and coiled, and there is one sessile gland at the orifice. Fridericia longeaurita sp.n. is large-sized with 4(5) chaetae per preclitellar bundle but only two or one in postclitellar bundles. The spermathecal ectal duct is shorter than the body diameter, with one small and sessile ectal gland at the orifice. Each ampulla has two long, ear-shaped, and sac-like diverticula. None of the three species were rare at the sites where they occurred.
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http://dx.doi.org/10.11646/zootaxa.3911.3.3 | DOI Listing |
Antimicrob Agents Chemother
August 2024
Translational Medicine, Biostatistics and Research Decision Sciences, Merck & Co., Inc., Rahway, New Jersey, USA.
Islatravir is a deoxynucleoside analog being developed for the treatment of HIV-1 infection. Clinical studies are being conducted to evaluate islatravir, administered in combination with other antiretroviral therapies, at doses of 0.25 mg once daily and 2 mg once weekly.
View Article and Find Full Text PDFJ Fungi (Basel)
January 2024
Programa de Pós-Graduação em Biodiversidade e Biotecnologia, Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus 69050-010, Brazil.
Pigments of fungal origin have aroused increasing interest in the food dye and cosmetic industries since the global demand for natural dyes has grown. Endophytic microorganisms are a source of bioactive compounds, and Amazonian plant species can harbor fungi with a wide range of biotechnological applications. Popularly known in Brazil as crajiru, is a medicinal plant that produces a red pigment.
View Article and Find Full Text PDFBMC Cardiovasc Disord
November 2023
Department of Cardiology, The Second People's Hospital of Hefei, Hefei Hospital, Anhui Medical University, Hefei, 230011, Anhui, China.
Background: The predictive utility of QTc values, calculated through various correction formulas for the incidence of postoperative major adverse cardiovascular and cerebrovascular events (MACCE) in patients experiencing acute myocardial infarction (AMI), warrants further exploration. This study endeavors to ascertain the predictive accuracy of disparate QTc values for MACCE occurrences in patients with perioperative AMI.
Methods: A retrospective cohort of three hundred fourteen AMI patients, comprising 81 instances of in-hospital MACCE and 233 controls, was assembled, with comprehensive collection of baseline demographic and clinical data.
Sci Rep
October 2023
Cardiovascular Aerospace Medicine, German Aerospace Center, Cologne, Germany.
The safety of prolonged high-altitude stays and exercise for physically fit post-myocardial infarction (MI) patients is unclear. Myocardial tissue hypoxia and pulmonary hypertension can affect cardiac function and electrophysiology, possibly contributing to arrhythmias. We included four non-professional male athletes, clinically stable after left ventricular MI (three with ST-segment elevation MI and one with non-ST-segment elevation MI) treated with drug-eluting stents for single-vessel coronary artery disease.
View Article and Find Full Text PDFDrugs R D
December 2023
Clinical Pharmacology and Pharmacometrics, Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.
Background And Objective: Tucatinib is a selective tyrosine kinase inhibitor of the human epidermal growth factor receptor 2 (HER2) approved to treat metastatic HER2-positive breast and colorectal cancers. The International Council for Harmonisation of Technical Requirements for Human Use (ICH) E14 guideline mandates that new drugs are assessed for potential effects on cardiac repolarization through electrocardiogram (ECG) evaluation in a QT/corrected QT (TQT) study.
Methods: We evaluated the effect of tucatinib on cardiac repolarization in healthy volunteers in a phase I, randomized, partially double-blind, placebo-and positive-controlled three-period crossover study.
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