AI Article Synopsis
- OrthoAlign is a new algorithm designed to tackle the gene order alignment problem, specifically for orthologs, by considering key evolutionary events like duplications and rearrangements.
- When applied to the tRNA gene repertoires of 50 bacteria from the Bacillus genus, it revealed that gene duplications and losses are more common than rearrangements.
- The study found that the rates of gene duplications and losses in Bacillus are significantly lower than in E. coli, indicating strong selective pressures on the tRNA genes in this genus.
Article Abstract
OrthoAlign, an algorithm for the gene order alignment problem (alignment of orthologs), accounting for most genome-wide evolutionary events such as duplications, losses, rearrangements, and substitutions, was presented. OrthoAlign was used in a phylogenetic framework to infer the evolution of transfer RNA repertoires of 50 fully sequenced bacteria in the Bacillus genus. A prevalence of gene duplications and losses over rearrangement events was observed. The average rate of duplications inferred in Bacillus was 24 times lower than the one reported in Escherichia coli, whereas the average rates of losses and inversions were both 12 times lower. These rates were extremely low, suggesting a strong selective pressure acting on tRNA gene repertoires in Bacillus. An exhaustive analysis of the type, location, distribution, and length of evolutionary events was provided, together with ancestral configurations. OrthoAlign can be downloaded at: http://www.iro.umontreal.ca/~mabrouk/.
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| http://dx.doi.org/10.1093/molbev/msv029 | DOI Listing |
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