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[An unusual tricuspid regurgitation].
G Ital Cardiol (Rome)
January 2025
U.O. Cardiologia, Dipartimento di Specialità Medico-Chirurgiche, Scienze Radiologiche e Sanità Pubblica, Università degli Studi, Brescia.
Tricuspid regurgitation can be due to different causes and mechanisms. Among these, cardiac involvement in carcinoid disease is a rare cause of tricuspid valve disease with a peculiar echocardiographic aspect. We report the case of a 59-year-old woman, with no past medical history, who was recently found to have a heart murmur and signs of right heart failure.
View Article and Find Full Text PDFSerum and urinary 5-hydroxyindolacetic acid, serotonin, chromogranin A, and NT-proBNP for the detection of carcinoid heart disease.
Eur J Endocrinol
November 2024
Service de Biochimie et biologie moléculaire, Hospices Civils de Lyon, Bron 69500, France.
Objective: The aim of this study was to evaluate the performance of different biomarkers for the detection of carcinoid heart disease (CHD) in neuroendocrine tumours (NETs), in particular serum 5-HIAA (s5HIAA).
Design: An explorative ancillary study of the French CrusoeNET cohort.
Methods: Patients managed in the Lyon-EURACAN Center of Excellence (CoE) were included when they were aged of at least 18 years, treated and followed for an advanced/metastatic ileum or lung NET, a NET irrespective of the primary location or from unknown primary location but with clinical CS, and/or elevation of urinary 5-HIAA (u5HIAA) twice greater than the upper limit of normal.
Percutaneous Pulmonary Valve Implantation With Self-Expanding Valves for Carcinoid Heart Diseases.
Catheter Cardiovasc Interv
January 2025
Department of Paediatric and Adult Congenital Heart Disease, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Carcinoid heart disease is an important complication of neuroendocrine tumors that may lead to significant morbidity and mortality. Right-sided heart valve involvement with consequent valve dysfunction is one of the common manifestations. Patients often have multiple, significant comorbidities with advanced metastatic disease and, as such, may not be suitable for surgical valve replacement due to excessive risk.
View Article and Find Full Text PDFCarcinoid heart findings in vasoactive intestinal peptide-secreting tumour.
BMJ Case Rep
November 2024
Division of Cardiology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
Article Synopsis
- - Diagnosis of tricuspid valve disease in patients with carcinoid heart syndrome is often done with echocardiography, especially in those already diagnosed with carcinoid syndrome.
- - VIPoma is a rare type of tumor occurring in 0.05%-2% of cases, causing symptoms like flushing, diarrhea, and electrolyte issues without typically affecting heart valves.
- - In a notable case, detection of tricuspid regurgitation and stenosis during echocardiography led to a quicker investigation for cancer, ultimately revealing the presence of VIPoma.
Carcinoid heart disease in patients with advanced small-intestinal neuroendocrine tumors and carcinoid syndrome: a retrospective experience from two European referral centers.
ESMO Open
November 2024
Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, Milan. Electronic address:
Article Synopsis
- * A study analyzed 165 stage IV SI-NET patients between 2015 and 2021, revealing that 25% developed CHD, particularly moderate-to-severe tricuspid insufficiency, and had a median OS of 4.5 years after CHD diagnosis.
- * The research highlights the importance of screening and monitoring for CHD in patients with CS, as CHD significantly worsens prognosis, with a hazard ratio for OS
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