AI Article Synopsis
- The study aimed to create fast dissolving films for delivering quercetin nanocrystals, using maltodextrins as the main material and glycerin for flexibility, to improve quercetin's oral absorption.
- Quercetin nanosuspensions were made using a high-pressure homogenizer and then used to make the films through a casting method; analysis showed that reducing quercetin to nanoscale didn't alter its solid form within the films.
- The presence of quercetin nanocrystals in the films changed their properties, making them more elastic and ductile, while the dissolution rate of both the free and film-embedded quercetin was significantly higher compared to regular quercetin.
Article Abstract
The objective of this study was to evaluate the feasibility to prepare fast dissolving films as quercetin nanocrystal delivery systems, using maltodextrins as film forming material and glycerin as plasticizer, with the goal of enhancing quercetin oral bioavailability. Quercetin nanosuspensions were prepared using a high-pressure homogenizer, and then directly used to prepare the films by a casting method. Spectroscopic and calorimetric analysis evidenced that reduction of quercetin size at nanoscale and incorporation in maltodextrin films do not affect the solid state of the active ingredient. The loading of quercetin nanocrystals into the film determined a slight variation of film elasticity and ductility. Indeed, the elastic modulus of the loaded films resulted about a half of the placebo ones, while the elongation at break increased four folds. Free and film loaded quercetin nanocrystals showed a comparable dissolution rate, much higher than that of bulk quercetin.
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| http://dx.doi.org/10.1016/j.carbpol.2014.11.070 | DOI Listing |
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